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European Journal of Clinical Pharmacology

, Volume 32, Issue 4, pp 431–432 | Cite as

Comparative pharmacokinetics of theophylline following two fluoroquinolones co-administration

  • M. Sano
  • I. Yamamoto
  • J. Ueda
  • E. Yoshikawa
  • H. Yamashina
  • M. Goto
Letter To The Editors

Summary

Pretreatment for 3 days with oral ofloxacin or norfloxacin had no significant effect on the disposition of a single i.v. dose the theophylline in healthy volunteers.

Key words

theophylline fluoroquinolones drug interaction pharmacokinetics ofloxacin norfloxacin 

References

  1. 1.
    Wijnands WJA, Vree TB, Van Herwaarden CLA (1986) The effect of the 4-quinolone enoxacin on plasma theophylline concentrations. Pharm Weekbl [Sci] 8: 42–45Google Scholar
  2. 2.
    Yamaoka K, Tanigawara Y, Nakagawa T, Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharm Dyn 4: 879–885Google Scholar
  3. 3.
    Pfeifer HJ, Greenblatt DJ, Paul Friendman MD (1979) Effect of three antibiotics on theophylline kinetics. Clin Pharmacol Ther 26: 36–40Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Sano
    • 1
  • I. Yamamoto
    • 1
  • J. Ueda
    • 1
  • E. Yoshikawa
    • 1
  • H. Yamashina
    • 1
  • M. Goto
    • 2
  1. 1.Departments of Hospital PharmacyTenri HospitalTenri, NaraJapan
  2. 2.Nagoya Memorial HospitalNagoyaJapan

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