European Journal of Clinical Pharmacology

, Volume 32, Issue 4, pp 335–338 | Cite as

Magnesium depletion in patients on long-term chlorthalidone therapy for essential hypertension

  • G. Cocco
  • H. U. Iselin
  • C. Strozzi
  • B. Cesana
  • H. R. Baumeler


Sixty patients were treated for 1 year for essential uncomplicated hypertension, 30 with beta-blockers alone (BB) and 30 with BB and chlorthalidone (CTD). BB did not affect serum K+ or Mg++. In the BB-group there was a statistically significant trend towards retention of Mg++ in a loading test, but the effect was clinically marginal. BB + CTD reduced serum K+ and Mg++ and caused significant Mg++ depletion, as shown by the Mg++ loading test. All the effects were highly significant and were clinically important. The metabolic perturbations due to CTD are potentially dangerous and make this drug unattractive as ‘first choice’ treatment for hypertension.

Key words

chlorthalidone magnesium depletion hypertension adverse effect 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • G. Cocco
    • 1
    • 2
  • H. U. Iselin
    • 3
  • C. Strozzi
    • 2
  • B. Cesana
    • 4
  • H. R. Baumeler
    • 1
  1. 1.Rehabilitationszentrum SolbadklinikRheinfeldenSwitzerland
  2. 2.Medical Clinics and Therapeutics, School of MedicineUniversity of FerraraFerraraItaly
  3. 3.Medical DepartmentRegionalspitalRheinfeldenSwitzerland
  4. 4.Institute of Medical SciencesUniversità degli studiMilanoItaly

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