Virchows Archiv A

, Volume 350, Issue 3, pp 275–287 | Cite as

Einbaurate von Enzymeiweißen in das Rattenpankreas nach Adrenalektomie unter Cortison

  • M. Wanke
  • K. Wegener
  • H. Lahmann

The incorporation of enzyme-proteins in the pancreas of the adrenalectomized rat treated with cortisone


Ten days after bilateral adrenalectomy there is a statistically significant decrease (−71%) in proteolytic enzymes of the pancreatic acinar cells. Application of cortisone on the 10th day after bilateral adrenalectomy is followed 4 hours later by an increase (+ 12% as compared with controls) of trypsin. Autoradiographic studies show a direct proportionality between the silver grains and the aminoacid incorporation presumed. The grains in the nucleus are negligible. Therefore, participation of the nucleus in the production of proenzymes seems to be of no importance. The experiments demonstrate the close relation between the adrenal cortex and aminoacid uptake of the exocrine cells of the pancreas.

Cortisone-pancreatitis serves as a model. The results are comparable with the situation in humans.


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Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • M. Wanke
    • 1
  • K. Wegener
    • 1
  • H. Lahmann
    • 1
  1. 1.Pathologisches Institut der Universität HeidelbergGermany

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