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Erythromycin absorption in healthy volunteers from single and multiple doses of enteric-coated pellets and tablets

  • T. Hovi
  • K. Josefsson
  • O. V. Renkonen
Article

Summary

The absorption of erythromycin from two different enteric-coated preparations was evaluated in three groups of healthy volunteers. After a single dose, taken after an overnight fast, absorption was significantly better from enteric-coated pellets than from tablets; both the mean peak serum concentration and the peak mean level were higher (p<0.01) in all three groups, and the mean area under the serum concentration-time curve (AUC) was at least 65% larger. Eight out of 23 subjects showed no or only a very low serum concentration after the enteric-coated tablets. In a follow-up study, 250 mg doses were given 6-hourly for 3 days, and again the mean maximum serum concentration was significantly higher (p<0.05) after the pellets. In conclusion, enteric-coated pellets led to more regular and predictable absorption of erythromycin than did coated tablets.

Key words

erythromycin tablets absorption enteric-coated pellets blood concentrations healthy volunteers pharmacokinetics 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • T. Hovi
    • 1
  • K. Josefsson
    • 3
  • O. V. Renkonen
    • 2
  1. 1.Department of VirologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of Bacteriology and ImmunologyUniversity of HelsinkiHelsinkiFinland
  3. 3.Clinical ResearchAstra Läkemedel ABSödertäljeSweden

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