Summary
The pharmacokinetics of indoramin (Baratol®) have been studied in five male and five female healthy, middle-aged volunteers after intravenous administration (0.14 mg/kg). Elimination occurred in an apparently biexponential fashion with a mean elimination half-life of 4.0h (±0.25 SEM). The mean plasma clearance was 19.9 ml/min/kg (±1.32 SEM) and the mean volume of distribution 7.4 l/kg (±0.81 SEM). There were no significant differences in these parameters between male and female volunteers. Protein binding of indoramin ranged from 85.6% at 81 ng/ml to 72.2% at 129 µg/ml. Two classes of binding site were evident, with affinity constants of 6.85×104M−1 and 4.30×103M−1.
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Norbury, H.M., Franklin, R.A., Marrott, P.K. et al. Pharmacokinetics of intravenous indoramin in middle-aged male and female volunteers. Eur J Clin Pharmacol 25, 243–246 (1983). https://doi.org/10.1007/BF00543798
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DOI: https://doi.org/10.1007/BF00543798