European Journal of Clinical Pharmacology

, Volume 25, Issue 2, pp 207–210 | Cite as

Fasting and postprandial absorption of digoxin from a microencapsulated formulation

  • B. Bergdahl
  • C. Bogentoft
  • U. E. Jonsson
  • J. O. Magnusson
Article

Summary

The absorption of digoxin from a capsule preparation containing a large number of small, enteric-coated granules of the glycoside (Preparation CR) was compared in 10 volunteers with that from a rapidly dissolving tablet (Preparation L). Plasma and urine digoxin concentrations were measured by radioimmunoassay. In the fasting state, after a loading dose of digoxin (0.76 mg), peak plasma concentrations were significantly (p<0.001) lower after CR (2.0±0.5 nmol/l, mean±SD) than L (4.7±1.1 nmol/l). Peak concentrations after CR were significantly (p<0.001) delayed compared to L (3.3±0.6 h vs 1.1±0.4 h). Also, postprandial peak plasma concentrations at steady state, were significantly (p<0.01) lower after CR (1.0±0.3 nmol/l) than L (2.7±0.5 nmol/l), and the peak concentrations occurred later (3.9±1.7 h vs 1.4±0.9 h). The area under the plasma concentration-time curves was smaller (p<0.01) for CR (17.7±5.9 nmol·l−1·h) than for L (22.4±4.1 nmol·l−1·h), and so was the amount of drug excreted in urine (174±25 µg vs 190±31 µg; p<0.005). Thus, the absorption rate of digoxin from the enteric-coated formulation was markedly reduced but at the cost of a variable reduction in the amount absorbed.

Key words

digoxin absorption enteric coating radioimmunoassay urinary digoxin plasma digoxin dissolution rate 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • B. Bergdahl
    • 1
  • C. Bogentoft
    • 2
  • U. E. Jonsson
    • 2
  • J. O. Magnusson
    • 1
  1. 1.Departments of Clinical Pharmacology and Internal Medicine, Division of CardiologyUniversity HospitalLinköpingSweden
  2. 2.Department of PharmaceuticsAB HässleMölndalSweden

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