Summary
Ketotifen 1 mg b.d. (oral) and sodium cromoglycate 20 mg q.i.d. (inhalation) were compared in a double-blind crossover trial in 43 asthmatic outpatients. Comparison of diary card scores and pulmonary function tests showed significant improvement over a 12 week period on each drug. Comparison of the diary card scores and pulmonary function tests showed no significant difference between the drugs after 12 weeks of treatment. Twenty-six patients experienced sedation and/or lethargy whilst on ketotifen and 11 patients had similar side effects whilst on cromoglycate. Physician preferences based on diary card and pulmonary function data showed an approximately equal number of preferences for each medication and also a small group of patients in which no preference could be made. The present trial suggests that both ketotifen and cromoglycate are effective in the management of outpatient asthma. When all the patients are considered as a group no distinction can be made between the two drugs; on the basis of physician assessment of each patient, it appears that some patients may do better on ketotifen and others on cromoglycate.
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References
Martin U, Römer D (1978) The pharmacological properties of a new orally active antianaphylactic compound: Ketotifen, a benzocycloheptathiopene. Arzneimittelforsch/Drug Res 28: 770–782
Lichtenstein LM, Gillespie E (1975) The effects of the H1 and H2 antihistamines on ‘allergic’ histamine release and its inhibition by histamine. J Pharmacol Exp Ther 192: 441–450
Martin U, Römer D (1978) Anti-anaphylactic properties of ketotifen in animal experiments. Triangle 17 [3–4]: 147–147
Church MK, Gradidge CF (1980) Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol 69: 663–667
Craps L, Greenwood C, Radielovic P (1978) Clinical investigation of agents with prophylactic anti-allergic effects in bronchial asthma. Clin Allergy 8: 373–382
Weheba AF (1978) Clinical assessment of the efficacy and tolerance of ketotifen in bronchial asthma. Pharmatherapeutica 2: 85–90
Clarke CW, May CS (1980) A comparison of the efficacy of ketotifen (HC20-511) with sodium cromoglycate (SCG) in skin test positive asthma. Br J Clin Pharmacol 10: 473–476
Lane DJ (1980) A steroid sparing effect of ketotifen in steroid-dependent asthmatics. Clin Allergy 10: 519–525
Pauwels R, Lamont H, Van Der Straeten M (1978) Comparison between ketotifen and DSCG in bronchial challenge. Clin Allergy 8: 289–293
Kennedy JD, Hasham F, Clay MJD, Jones RS (1980) Comparison of actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction in childhood asthma. Br Med J 281: 1458
Tanser AR, Elmes J (1980) A controlled trial of ketotifen in exercise induced asthma. Br J Chest 74: 398–401
Groggins RC, Hiller EJ, Milner AD, Stokes GM (1981) Ketotifen in the prophylaxis of childhood asthma. Arch Dis Child 56: 304–305
Dyson AJ, Mackay AD (1980) Ketotifen in adult asthma. Br Med J 280: 360–361
Monie RDH, Smith AP, Leopold JD, Anderson EG, Davies BH, Thomas GO (1981) Double blind clinical trial of ketotifen and disodium cromoglycate in bronchial asthma. Thorax 36: 234
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Paterson, J.W., Yellin, R.H. & Tarala, R.A. Evaluation of ketotifen (HC20-511) in bronchial asthma. Eur J Clin Pharmacol 25, 187–193 (1983). https://doi.org/10.1007/BF00543789
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DOI: https://doi.org/10.1007/BF00543789