Virchows Archiv A

, Volume 361, Issue 1, pp 39–50 | Cite as

Zur Ultrastruktur der Hypophysenadenome beim Cushing-Syndrom nach Adrenalektomie

  • W. Saeger

Ultrastructure of pituitary adenomas in Cushing's syndrome after adrenalectomy


Four pituitary tumors of patients adrenalectomized for bilateral adrenal hyperplasia with Cushing's syndrome 4–12 years before, were classified histologically as mucoid cell adenomas. Histochemically the tumor cells reacted like normal ACTH cells. The ultrastructure showed cells with multipolar outlines tending to surround other cells, large Golgi complexes, many immature secretory granules, a lot of mature granules with perigranular membranes and 200–600mµ in diameter, scattered particles of endoplasmic reticulum, a great abundance of ribosomes, pleomorphic mitochondria, a few small accumulations of fine filaments, and moderate pleomorphism of the nuclei with distinct nucleoli and sporadically cytoplasmic invaginations. It can be assumed that these adenomas developed from hyperplasias of ACTH cells. In all cases elevated levels of ACTH had been found in the plasma.


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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • W. Saeger
    • 1
  1. 1.Pathologisches Institut der Universität HamburgGermany

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