Summary
It is widely accepted that angiotensin II, ACTH and potassium are the major factors controlling the release of aldosterone. Conflicting results have been reported about the role of serotonin, dopamine and histamine. To evaluate the possible involvement of H2-histaminergic receptors, the effect of intravenous injection of 400 mg cimetidine on the renin-angiotensin-aldosterone system has been evaluated in 10 healthy volunteers. The administration of cimetidine did not induce a significant change in plasma aldosterone level or in its major controlling factors.
References
Simpson SAS, Tait JF, Wettstein A, Neher R, Von Euw J, Reichstein T (1953) Isolierung eines neuen kristallisierten Hormons aus Nebennieren mit besonders hoher Wirksamkeit auf den Mineralstoffwechsel. Experientia 9: 333–336
Edwards CRW, Al-Dujaili EAS, Boscaro M, Gow I, William BC (1982) Peptidergic and monoaminergic regulation of aldosterone secretion. In: Mantero F, Biglieri EG, Edwards CRW (eds) Endocrinology of hypertension. Academic Press, London New York, p 11–18
Barbieri C, Caldara R, Ferrari C, Crossignani RM, Recchia M (1981) Inhibition of the renin-angiotensin-aldosterone system by L-dopa with and without inhibition of extracerebral dopa decarboxylase in man. Clin Sci 61: 187–190
Aikawa T, Hirose T, Matsumoto I, Suzuki T (1979) Secretion of aldosterone in response to histamine in hypophysectomized-nephrectomized dogs. J Endocrinol 81: 325–330
Gross MD, Grekin RJ, Gniadek TC, Villareal JZ (1981) Suppression of aldosterone by cyproheptadine in idiopathic aldosteronism. N Engl J Med 305: 181–185
Freely J, Robertson D, Island DP, Wood AJJ (1982) Cimetidine alters plasma catecholamine levels and cortisol and aldosterone secretion. N Engl J Med 306: 1054
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Barbieri, C., Caldara, R., Cambielli, M. et al. Lack of effect of cimetidine on the renin-angiotensin-aldosterone system in man. Eur J Clin Pharmacol 26, 645–646 (1984). https://doi.org/10.1007/BF00543503
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DOI: https://doi.org/10.1007/BF00543503