European Journal of Clinical Pharmacology

, Volume 26, Issue 5, pp 591–593 | Cite as

Effect of liver failure on the pharmacokinetics of cyclophosphamide

  • F. D. Juma


The pharmacokinetics of cyclophosphamide was investigated in 7 patients in severe liver failure. The pharmacokinetic data were compared with those derived from a matched control group of patients with normal liver function. The half-life (t1/2) of cyclophosphamide following intravenous administration in patients with liver failure was 12.5±1.0 h (m±SD), which was significantly longer than in the normal controls in whom it was 7.6±1.4 h (p<0.001). The mean total body clearance (Clt) was significantly smaller in liver failure at 44.8+8.6l·kg−1 than in the controls in whom it was 63.0±7.6l·kg−1 (p<0.01). It is concluded that severe liver disease has a significant effect on the disposition of cyclophosphamide, and that it could lead to accumulation of the drug in the body.

Key words

cyclophosphamide liver failure pharmacokinetics 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • F. D. Juma
    • 1
  1. 1.Department of Medicine, College of Health SciencesUniversity of NairobiNairobiKenya

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