European Journal of Clinical Pharmacology

, Volume 28, Issue 3, pp 333–337 | Cite as

Pharmacokinetic studies of cefoxitin in continuous ambulatory peritoneal dialysis

  • A. Arvidsson
  • G. Alván
  • A. Tranaeus
  • A. S. Malmborg
Originals

Summary

The pharmacokinetics of cefoxitin was examined in 9 patients undergoing peritoneal dialysis for chronic renal failure. Cefoxitin was administered intraperitoneally in the dialysate fluid every 6 h for 24 h, in two different concentrations, 50 µg/ml and 100 µg/ml.

The plasma half-life of cefoxitin was 20.2 h. The major route of elimination was non-renal, with a clearance of 8.0 ml/min. Peritoneal clearance was 4.1 ml/min. As expected, renal clearance was negligible.

The peak plasma concentrations of cefoxitin at the two dose levels used were 7 µg/ml and 15 µg/ml, respectively, when assayed by HPLC, and 12 µg/ml and 24 µg/ml when determined by a microbiological assay. The cefoxitin concentration in the dialysate decreased from 50 µg/ml to 14 µg/ml and from 100µg/ml to 37 µg/ml during the 6 h of its retention in the peritoneal cavity.

Key words

cefotoxin renal failure peritoneal dialysis pharmacokinetics CAPD (continuous ambulatory dialysis) dialysate concentration intra peritoneal administration 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. Arvidsson
    • 1
  • G. Alván
    • 1
  • A. Tranaeus
    • 2
  • A. S. Malmborg
    • 3
  1. 1.Department of Clinical PharmacologyHuddinge University HospitalHuddingeSweden
  2. 2.Department of Renal MedicineHuddinge University HospitalHuddingeSweden
  3. 3.Department of MicrobiologyHuddinge University HospitalHuddingeSweden

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