Virchows Archiv A

, Volume 360, Issue 2, pp 155–171 | Cite as

Liver necrosis, adenovirus type 2 and thymic dysplasia

  • K. Aterman
  • J. Embil
  • K. B. Easterbrook
  • E. V. Haldane
  • J. Crosby
Article

Summary

An association between adenovirus and liver cell damage, although suspected, has not been frequently demonstrated in the human. In this presentation the necropsy of a two month old female infant with thymic dysplasia will be reported who died with liver necrosis in the absence of pulmonary changes. Sections of the liver showed numerous Feulgen-positive intranuclear inclusions with a distinct mosaic-like pattern on high magnification. Adenovirus was isolated from the liver and identified as type 2 by hemagglutination-inhibition and neutralisation tests. Electronmicroscopy of the liver showed considerable multiplication of the virus in most of the liver cells. The characteristic para-crystalline array of the virions could frequently be seen. The appearance of the virion, its size, and cellular distribution was typical of an adenovirus.

This appears to be the first instance in which adenovirus has actually been shown by electron-microscopy in the human liver, and the third instance in which liver necrosis due to adenovirus was associated with thymic dysplasia.

Keywords

Public Health Liver Cell Cell Damage Human Liver High Magnification 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Angella, J. J., Connor, J. D.: Neonatal infection caused by adenovirus type 7. J. Pediat. 72, 474 (1968).Google Scholar
  2. Benyesh-Melnick, U., Rosenberg, H. S.: The isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. J. Pediat. 64, 83 (1964).Google Scholar
  3. Davis, E. V.: Isolation of viruses from children with infectious hepatitis. Science 133, 2059 (1961).Google Scholar
  4. Duic, A., Crozier, D. N., McClure, P. D.: Swiss agammaglobulinemia with hypoglycemia, osseous changes and eosinophilia. Canad. med. Ass. J. 103, 64 (1970).Google Scholar
  5. Dvořáčková, I., Vortel, V., Hroch, M.: Encephalitic syndrome with fatty degeneration of viscera. Arch. Path. 81, 240 (1969).Google Scholar
  6. Embil, J., Faulkner, R. S.: Human diploid cell strains and their susceptibility to viruses. Canad. J. publ. Hlth 55, 111 (1964).Google Scholar
  7. Hartwell, W. V., Love, G. J., Eidenbock, M. P.: Adenovirus in blood clots from cases of infectious hepatitis. Science 152, 1390 (1966).Google Scholar
  8. Haworth, J. C., Hoogstraten, J., Taylor, H.: Thymic alymphoplasia. Arch. Dis. Childh. 42, 40 (1967).Google Scholar
  9. Herrmann, E. C.: Experience in laboratory diagnosis of adenovirus infections in routine medical practice. Mayo Clin. Proc. 43, 635 (1968).Google Scholar
  10. Hillis, W. D.: Cited by W. B. Strong. Adenovirus isolations from patients with infectious hepatitis. CDC Hepatitis Surveillance Report No. 22, p. 17, Atlanta, Georgia (1965).Google Scholar
  11. Köhler, H., Apodaca, J., Lange, W.: Hepatitis bei Affen nach Verimpfung von Adenoviren aus Menschen mit Virushepatitis. — IV. Immunisierungs- und Belastungsversuche. Zbl. Bakt. 209, 423 (1968).Google Scholar
  12. Köhler, H., Apodaca, J., Springer, D.: Über die mehrmalige Isolierung bisher beim Menschen unbekannter Adenoviren aus Patienten mit Virushepatitis mit Hilfe histologischer Verfahren. Zbl. Bakt. 202, 11 (1967).Google Scholar
  13. Kusano, N., Kawai, K., Aoyama, Y.: Intranuclear inclusion body in fatal infantile pneumonia due to adenovirus. Jap. J. exp. Med. 28, 301 (1958).Google Scholar
  14. Mollenhauer, H. M.: Plastic embedding mixtures for use in electron microscopy. Stain Technol. 39, 111 (1964).Google Scholar
  15. Rose, H. M.: The adenoviruses. In: Diagnostic procedures for viral and rickettsial diseases, 4th. ed., edited by E. H. Lennette and N. J. Schmidt, p. 205, New York: American Public Health Association Inc. 1969.Google Scholar
  16. Rosen, L.: A hemagglutination-inhibition technique for typing adenoviruses. Amer. J. Hyg. 71, 120 (1960).Google Scholar
  17. Sell, S.: Immunological deficiency diseases. Arch. Path. 86, 95 (1968).Google Scholar
  18. Sterner, G.: Adenovirus infection in childhood. An epidemiological and clinical survey among Swedish children. Acta. paediat/Uppsala, Suppl. 142 (1962).Google Scholar
  19. Strong, W. B.: Adenovirus isolation from patients with infectious hepatitis. CDC Hepatitis Surveillance Report No. 22, p. 17, Atlanta, Georgia (1965).Google Scholar
  20. Waldman, T.: Disorders of immunoglobulin metabolism. New Engl. J. Med. 281, 1170 (1969).Google Scholar
  21. Wigger, H. J., Blanc, W. A.: Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. New Engl. J. Med. 275, 870 (1966).Google Scholar
  22. Zuckerman, A. J.: Virus diseases of the liver. London: Butterworth & Co. Ltd. 1970.Google Scholar
  23. Zuckerman, A. J., Bird, R. G., Dunkley, R. J., Love, G. J.: Examination by electron microscope of the San Carlos viruses isolated from children with infectious hepatitis. J. clin. Path. 22, 40 (1969).Google Scholar

Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • K. Aterman
    • 1
  • J. Embil
    • 1
  • K. B. Easterbrook
    • 1
  • E. V. Haldane
    • 1
  • J. Crosby
    • 1
  1. 1.Departments of Pathology, MicrobiologyMedicine and Pediatrics of Dalhousie University and the Izaak Walton Killam Hospital for ChildrenHalifaxCanada

Personalised recommendations