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Humoral conditioning for necrosis

Part I the conditioning factors

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Zusammenfassung

Nach Vorbehandlung mit verschiedenen Mastzellentladern, Histamin, oder Serotonin, bilden sich bei der Ratte an Stellen, wo sonst gut vertragene Dosen hypertonischer Lösungen subcutan injiziert werden, ausgedehnte Hautnekrosen aus. Viele andere, in ihrer chemischen Struktur und pharmakologischen Aktivität sehr verschiedene Agenzien, sowie schwere Stressoren sind in dieser Beziehung inaktiv.

Summary

Otherwise well tolerated amounts of subcutaneously injected hypertonic solutions produce extensive local skin necroses in rats pretreated with a variety of mast-cell dischargers, histamine or serotonin. Numerous other agents, differing widely in chemical structure and pharmacologic activity, as well as severe stressors proved to be devoid of this effect.

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Authors and Affiliations

  1. Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada

    Hans Selye, Pavel Rohan & Ung Soo Pahk

Authors
  1. Hans Selye
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  2. Pavel Rohan
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  3. Ung Soo Pahk
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Selye, H., Rohan, P. & Pahk, U.S. Humoral conditioning for necrosis. Naunyn-Schmiedebergs Arch. Pharmak. u. Exp. Path. 255, 133–141 (1966). https://doi.org/10.1007/BF00543207

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  • DOI: https://doi.org/10.1007/BF00543207

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