Virchows Archiv A

, Volume 351, Issue 2, pp 87–98 | Cite as

Ultrastructure of the thyroid in De Quervain's subacute granulomatous thyroiditis

  • Pierre Nève
Article

Summary

An electron microscope study of excised thyroid fragments from a case of De Quervain's subacute thyroiditis is reported. Deposit of material along the basement membrane making the latter apparently thickened, cytoplasmic alterations and stratification of thyroid cells seem to be induced by the thyroiditis process itself. The characteristic giant cells are syncytia resulting from fusion of inflammatory cells. The pathology is specific of a granuloma and is strikingly different from that of the other thyroidites.

Keywords

Public Health Electron Microscope Stratification Inflammatory Cell Basement Membrane 

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References

  1. Batolo, D., Martines, F., Carrozza, G.: Morphogénèse, histochimie et signification des structures gigantocellulaires dans les thyroidites idiopathiques. Path. europ. 3, 80–95 (1967).Google Scholar
  2. Bernhard, W., Leplus, R.: Structure fine du ganglion humain normal et malin. Paris: Gauthier-Villars Macmillan 1964.Google Scholar
  3. Binet, J. L., Gennes, J. L. de, Decourt, J.: Étude cytologique en microscopie électronique de l'infiltration lympho-plasmocytaire dans deux cas de thyroidite d'Hashimoto. Rev. franç. Étud. clin. biol. 8, 1011–1017 (1963).Google Scholar
  4. Bonnyns, M.: Dosage de l'hormone thyréotrope et du “Long-Acting Thyroid Stimulator” par la technique de McKenzie. Étude critique de la méthode. Rev. franc. Etud. clin. biol. 13, 845–852 (1968).Google Scholar
  5. Clark, S. L.: The reticulum of lymph nodes in mice studied with the electron microscope. Amer. J. Anat. 110, 217–257 (1962).Google Scholar
  6. Goetsch, E.: Origin, evolution and significance of giant cells in Riedel's struma. Arch. Surg. 41, 308–323 (1940).Google Scholar
  7. Gusek, W.: Über die Ultrastruktur und Natur der Epitheloidzellen. Frankfurt. Z. Path. 69, 685–694 (1959).Google Scholar
  8. -- Submikroskopische Untersuchungen zur Feinstruktur aktiver Bindegewebszellen, Chap. 4: Riesenzellen; p. 48–61 in Veröffentlichungen aus der Morphologischen Pathologie H. 64, 1–115 (1962).Google Scholar
  9. —— Naumann, P.: Elektronenoptische Untersuchungen am tuberkulösen Granulationsgewebe. Verh. dtsch. Ges. Path. 43, 254–257 (1959).Google Scholar
  10. Heimann, P.: Ultrastructure of human thyroid. A study of normal thyroid, untreated and treated diffuse toxic goitre. Acta endocr. (Kbh.), Suppl. 110, 1–102 (1966).Google Scholar
  11. Hovig, T., Dodds, W. J., Rowsell, H. C., Mustard, J. F.: The transformation of hemostatic platelet plugs in normal and factor IX deficient dogs. Amer. J. Path. 53, 355–374 (1968).Google Scholar
  12. Irvine, W. J., Muir, A. R.: An electron microscopic study of Hashimoto thyroiditis. Quart. J. exp. Physiol. 48, 13–26 (1963).Google Scholar
  13. Lindsay, S., Dailey, M. E.: Granulomatous or giant cell thyroiditis: clinical and pathologic study of 37 patients. Surg. Gynec. Obstet. 98, 197–212 (1954).Google Scholar
  14. Meachim, S., Young, M. H.: De Quervain's subacute granulomatous thyroiditis: histological identification and incidence. J. clin. Path. 16, 189–199 (1963).Google Scholar
  15. Millonig, G.: Further observations on a phosphate buffer for osmium solutions. V. Int. Congr. Electron Microscopy, p. 88. Philadelphia: Academic Press 1962.Google Scholar
  16. Nadler, N. J., Young, B. A., Leblond, C. P., Mitmaker, B.: Elaboration of thyroglobulin in the thyroid follicle. Endocrinology 74, 333–354 (1964).Google Scholar
  17. Nève, P.: Ultrastructure des cellules folliculaires d'une thyroïde humaine normale. J. Microse. 4, 811–814 (1965).Google Scholar
  18. —— The ultrastructure of thyroid in chronic autoimmune thyroiditis. Virchows Arch. Abt. A Path. Anat. 346, 302–317 (1969).Google Scholar
  19. Noseda, I.: Elektronenmikroskopische Untersuchungen an der normalen Schilddrüse mit besonderer Berücksichtigung der Sekretionsvorgänge. Z. mikr.-anat. Forsch. 60, 192–204 (1954).Google Scholar
  20. Okada, Y.: Factors in fusion of cells by H.V.J. Current Topics in Microbiology and Immunology 48, 102–128 (1969).Google Scholar
  21. Peach, R.: An electron optical study of experimental scurvy. J. Ultrastruct. Res. 6, 579–590 (1962).Google Scholar
  22. Persson, P. S.: Cytodiagnosis of thyroiditis. Acta med. scand., Suppl. 483, 1–100 (1968).Google Scholar
  23. Quervain, F. De: Die akute, nicht eiterige Tyreoiditis und die Beteilung der Schilddrüse an akuten Intoxikationen und Infektionen überhaupt. Mitt. Grenzgeb. Med. Chir., Suppl. 2, 1–165 (1904).Google Scholar
  24. Reynolds, E. S.: The use of lead citrate at high pH as electron opaque stain in electron microscopy. J. Cell Biol. 17, 208–213 (1963).Google Scholar
  25. Robertson, J. D.: The ultrastructure of cell membranes and their derivatives. In: The structure and function of subcellular components. Biochemical Society Symposium, No. 16, p. 3–43. London: Cambridge University 1959.Google Scholar
  26. Seman, G., Gérard-Marchant, R., Micheau, C.: Présence de flagelles dans les cellules thyroïdiennes humaines normales et tumorales. Ann. Anat. path. 13, 263–268 (1968).Google Scholar
  27. Söderström, N.: Puncture of goitres for aspiration biopsy. A preliminary report. Acta med. scand. 144, 237–244 (1952).Google Scholar
  28. Stuart, A. E., Allan, W. S. A.: The significance of basement-membrane changes in thyroid disease. Lancet 1958 II, 1204–1209.Google Scholar
  29. Toujas, L., Guelfi, J.: Sur l'ultrastructure de la glande thyroïde humaine. Z. Zellforsch. 94, 118–128 (1969).Google Scholar
  30. Volpé, R., Row, V. V., Ezrin, C.: Circulating viral and thyroid antibodies in subacute thyroiditis. J. clin. Endocr. 27, 1275–1284 (1967).Google Scholar
  31. Wanstrup, J., Christensen, H. E.: Sarcoidosis. Ultrastructural investigations on epithelioid cell granulomas. Acta path. microbiol. scand. 66, 169–185 (1966).Google Scholar
  32. Wetzel, B. K., Spicer, S. S., Wollman, S. H.: Changes in fine structure and acid phosphatase localization in rat thyroid cells following thyrotropin administration. J. Cell Biol. 25, 593–618 (1965).Google Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • Pierre Nève
    • 1
  1. 1.Department of Medicine, St. Pierre Hospital, Laboratory of Electron Microscopy, Faculty of MedicineUniversity of BrusselsBrusselsBelgium

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