Summary
The number of mast-cells in the renal cortex was determined in 41 cases of hepatic cirrhosis with ascites. In more than half of the cases there was a definite increase in mastcells as compared to normal and arteriolosclerotic kidneys.
The renal mastocytosis was considered a compensatory reaction counteracting the disturbed salt and water metabolism resulting from a secondary aldosteronism. The renal mastocytosis probably exerted its effect by means of heparin production on the basis of the aldosteron-inhibiting and/or renin-inhibiting action of heparin.
Zusammenfassung
Es wurde der Mastzellgehalt der Nierenrinde bei 41 Fällen von Lebercirrhose mit Ascites untersucht. Im Vergleich zu normalen und arteriolosklerotischen Kontrollnieren wurde in mehr als der Hälfte der Lebercirrhosefälle ein deutlicher Anstieg der Mastzellen gefunden.
Die renale Mastocytose wird als kompensatorische Reaktion zum Ausgleich des gestörten Salz-Wasser-Haushaltes bei sekundärem Aldosteronismus gedeutet. Der Wirkungsmechanismus der Mastocytose ist wahrscheinlich auf die Heparinproduktion zu beziehen, die unter bestimmten Voraussetzungen die Aldosteronsekretion relativ hemmen kann.
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Dévényi, I., Szücs, L., Tessmann, D. et al. Renale Mastocytose und sekundärer Aldosteronismus. Virchows Arch. Abt. A Path. Anat. 345, 238–244 (1968). https://doi.org/10.1007/BF00542680
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DOI: https://doi.org/10.1007/BF00542680