Zusammenfassung
5 Kälber und 5 Schweine wurden mit Angiostrongylus cantonensis infiziert, 3, 7, 14, 28 und 56 Tage nach der Infektion getötet und histologisch untersucht.
Alle Kälber, dagegen nur ein Schwein, zeigten morphologische Zeichen der Gehirnerkrankung.
3 Tage nach der Infektion wurden vereinzelt Larven und kleine Blutungen im Gehirn eines Kalbes gefunden. Nach 7, 14 und 28 Tagen waren zahlreiche Parasiten, perivasculäre Infiltrate und Granulome in Gehirn und Rückenmark zu beobachten. 56 Tage nach der Infektion waren nur noch vereinzelte perivasculäre Infiltrate nachweisbar.
7, 14 und 28 Tage nach der Infektion traten in der Umgebung mehrerer Rückenmarkwurzeln epidurale, intradurale und vereinzelt auch subdurale Entzündungsinfiltrate auf. Gleichzeitig fanden sich Parasiten unter der anliegenden Arachnoidea oder Pia.
Diese periradikulären Infiltrate werden als Immunitätsreaktion auf die von den Parasiten in den cerebrospinalen Liquor abgegebenen und entlang der Nervenwurzeln abfließenden Antigene betrachtet.
Die Wurzelsymptome in Fällen von menschlicher Angiostrongylose haben vermutlich dieselbe Pathogenese.
Summary
Five calves and 5 pigs experimentally infected with larvae of Angiostrongylus cantonensis were killed 3, 7, 14, 28, and 56 days after infection and histologically examined.
All 5 calves and only one pig showed morphological evidence of cerebral involvement.
Three days after infection, a few larvae and minute hemorrhages were found in the brain of one calf. At 7, 14, and 28 days, numerous parasites, perivascular cuffing, and granulomas were present in the brain and spinal cord. Fifty-six days after infection only a few scattered perivascular cuffs remained.
Surrounding some of the spinal nerve roots, 7, 14, and 28 days post infection, epidural, intradural, and sometimes subdural inflammatory infiltrates with eosinophils and mononuclear cells were found. Their occurrence was associated with the presence of the parasites under the adjoining arachnoidea or pia mater.
These periradicular infiltrates are believed to be an immune response to the antigens released by the parasites into the cerebrospinal fluid and subsequently leaking along the nerve roots. Radicular symptoms in human cases of angiostrongylosis are supposed to have similar pathogenesis.
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Supported by grant No. NB-04965 of the Institute of Neurological Diseases and Blindness, NIH, USPHS to Dr. Alicata. Published with the approval of the Director of the Hawaii Agricultural Experiment Station as Technical Paper No. 926.
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Jindrák, K. The pathology of radicular involvement in angiostrongylosis as observed in experimentally infected calves and pigs. Virchows Arch. Abt. A Path. Anat. 345, 228–237 (1968). https://doi.org/10.1007/BF00542679
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DOI: https://doi.org/10.1007/BF00542679