European Journal of Clinical Pharmacology

, Volume 25, Issue 6, pp 783–785 | Cite as

Pharmacodynamics and urine pharmacokinetics of three doses of piretanide

  • B. H. Meyer
  • F. O. Müller
  • H.-G. Grigoleit
  • E. E. Dagrosa
Originals

Summary

Three doses (3 mg, 6 mg and 12 mg) of piretanide, a new high ceiling diuretic, and placebo were given to 8 volunteers to investigate the relationship between the pharmacodynamic parameters, the dose and its urinary excretion. Intake of food and fluid were standardized from 48 h before until 24 h after drug administration. Urinary output, excretion of unchanged drug, and the excretion and clearance of Na+ and K+ were measured hourly for 7 h after treatment. A clear dose-response relationship was found for cumulative urinary output, cumulative excretion of Na+ and K+, clearance of Na+ and K+ and the urinary sodium/potassium ratio. A significant correlation was found between the net urine volume and the excretion of piretanide per time interval. The clearances of Na+ and K+ were significantly correlated with the excretion of piretanide. Clearance values correlated well with corresponding urine volumes.

Key words

piretanide urine K+ and Na+ clearance pharmacodynamic effects pharmacokinetic effects diuretic effects dose-response relationship trial design 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • B. H. Meyer
  • F. O. Müller
    • 1
  • H.-G. Grigoleit
    • 2
  • E. E. Dagrosa
    • 2
  1. 1.Department of PharmacologyUniversity of the Orange Free StateBloemfonteinRepublic of South Africa
  2. 2.Hoechst AGFrankfurtFederal Republic of Germany

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