European Journal of Clinical Pharmacology

, Volume 25, Issue 6, pp 739–742 | Cite as

Comparative efficacy of different methods of nebulising terbutaline

  • J. Z. Pedersen
  • A. Bundgaard


The efficacy of terbutaline inhaled from different aerosol systems was studied in 13 adult asthmatics. Terbutaline 1 mg was delivered from a pressurised aerosol, 1 and 4 mg were inhaled from a nebuliser, 1 mg was inhaled through a pressurised aerosol with a pear-shaped, 750 ml spacer, and 1 mg was inhaled from a nebuliser with Intermittent Positive Pressure Ventilation (I.P.P.V.). An open, randomized, cross-over design was used. The bronchodilator effect was evaluated by recording hourly flow-volume curves and the FEV1.0 for 5 h after treatment. No significant difference in bronchodilatation was observed after inhalation of 1 mg terbutaline from different aerosol systems, except following use of the nebuliser, which required approximately four times as much terbutaline to obtain the same effect as the ordinary spray.

Key words

terbutaline pressurised aerosol bronchial asthma pear-shaped extender IPPV bronchodilatation drug efficiency 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • J. Z. Pedersen
    • 1
  • A. Bundgaard
    • 1
  1. 1.Laboratory of Respiratory Physiology, Medical Department BRigshospitaletCopenhagenDenmark

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