Summary
Fifty-six malnourished Ethiopian children with tuberculosis classified in four nutrional groups (normal, underweight, marasmus and kwashiorkor), were given streptomycin 20 or 30 mg·kg−1 i.m.
The plasma concentration-time data revealed an increased apparent volume of distribution in children with kwashiorkor compared to normals. The total plasma clearance was low and did not differ between the nutrional groups. Thus, the half-life was prolonged only in kwashiorkor. The results could be explained by decreased protein binding in plasma and decreased renal clearance by glomerular filtration.
This is a preview of subscription content, log in via an institution to check access.
References
Buchanan N (1978) Drug kinetics in protein energy malnutrition. South Afr Med J: 53
Krishnaswamy K (1978) Drug metabolism and pharmacokinetics in malnutrition. Clin Pharmacokinet 3: 216
Editorial (1970) Classification of infantile malnutrition. Lancet 2: 302
Jalling B, Malmborg A-S, Lindman A, Boréus LO (1972) Evaluation of a micromethod for determination of antibiotic concentrations in plasma. Eur J Clin Pharmacol 4: 150–157
Metzler CM, Elfring GL, McEwen AJ (1974) NONLIN. The UpJohn Co, Kalamazoo, MI, USA
Rowland M, Tozer TN (1980) Clinical pharmacokinetics. Lea and Febiger, Philadelphia
Waterlow Jc (1984) Kwashiorkor revisited: The pathogenesis of oedema in kwashiorkor and its significance. Trans R Soc Trop Med Hyg 78: 436
Buchman N (1977) Drug-protein binding and protein energy malnutrition. S Afr Med J 52: 733
Prasad JS, Krishnaswamy K (1978) Streptomycin pharmacokinetics in malnutrition. Chemotherapy 24: 333
Bravo ME, Arancibia A, Jarpa S, Caprentier PM, Jahr AN (1982) Pharmacokinetics of gentamicin in malnourished infants. Eur J Clin Pharmacol 21: 499
Buchanan N, Davis MD, Eyberg C (1979) Gentamicin pharmacokinetics in kwashiorkor. Br J Clin Pharmacol 8: 451
Goodman Gilman A, Goodman LS, Rall TW, Murad F (1985) The pharmacological basis of therapeutics. MacMillan, New York
Alleyne GAO (1967) The effect of severe PCM on renal function of Jamaica children. Br J Nutr 39: 400
Herngren L, Boréus LO, Jalling B, Lagercrantz R (1977) Pharmacokinetic aspects of streptomycin treatment of neonatal septicemia. Scand J Infect Dis 9: 301
Axline SG, Simon HJ (1965) Clinical pharmacology of anti-microbials in premature infants I. Kanamycin, streptomycin and neonmycin. Antimicrob Agents Chemother 1964: 135
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bolme, P., Eriksson, M., Habte, D. et al. Pharmacokinetics of streptomycin in Ethiopian children with tuberculosis and of different nutritional status. Eur J Clin Pharmacol 33, 647–649 (1988). https://doi.org/10.1007/BF00542504
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00542504