Summary
In 31 patients with leg ulcers the wounds were randomly allocated to treatment either with a solution of streptokinase plus streptodornase in saline or physiological saline alone.
The occurrence of pus and debris in the wounds was evaluated by a “blinded” investigator at the initiation of treatment and on Days 5, 10 and 15.
In 12 out of 13 patients treated with the streptokinase-streptodornase solution and in 8 out of 16 saline-treated patients the wounds were clean by Day 10.
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References
Hellgren L, Vincent J (1977) Degradation and liquefaction effect of streptokinase-streptodornase and stabilized trypsin on necroses, crusts of fibrinoid, purulent exudate and clotted blood from leg ulcer. J Int Med Res 5: 334–337
Poulsen J, Kristensen VN, Brygger HE, Delikaris P (1983) Treatment of infected surgical wounds with Varidase. Acta Chir Scand 149: 245–248
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Forsling, E. Comparison of saline and streptokinase-streptodornase in the treatment of leg ulcers. Eur J Clin Pharmacol 33, 637–638 (1988). https://doi.org/10.1007/BF00542501
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DOI: https://doi.org/10.1007/BF00542501