Summary
The effect of picotamide on platelet function has been studied in vitro and ex vivo.
Picotamide at micromolar concentrations inhibited platelet aggregation induced by ADP, arachidonic acid and collagen, and it also inhibited the production of thromboxane A2 (TxA2). Unlike aspirin, picotamide did not affect the synthesis of prostacyclin by blood vessels.
In eight healthy subjects who took picotamide 1200 mg/d platelet aggregation and TxA2 production were inhibited.
Picotamide appears to be an antiplatelet drug that reduces TxA2 synthesis without affecting cyclooxygenase activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bertelè V, Cerletti C, Schieppati A, Di Minno G, De Gaetano G (1981) Inhibition of thromboxane synthetase does not necessarily prevent platelet aggregation. Lancet 1: 1057–1058
Bertelè V, Folange A, Tomasiek M, Chiabrando C, Cerletti C, De Gaetano G (1984) Pharmacological inhibition of thromboxane synthetase and platelet aggregation: Modulatory role of cyclooxygenase products. Blood 6: 1460–1466
Cordova C, Musca A, Violi F, Alessandri C, Perrone A, Balsano F (1985) Platelet hyperfunction in patients with airway obstruction. Eur J Resp Dis 66: 9–12
Deckmyn BOH, Gresele P, Van Outte E, Nenci G, Vermylen J (1985) Synergism of a thromboxane (Tx) synthetase inhibitor (TSI) and a Tx receptor antagonist (TRA) in reducing platelet aggregation. Thromb. Haemostas 54: 1–372 (abstract)
Fitzgerald GA, Oates JA, Hawinger J, Moas RL, Roberts LJ, Lawson JA, Brash AR (1983) Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 71: 676–688
Heptinstall S, Bevan J, Cockbill SR, Hanley SP, Parry MJ (1980) Effect of a selective inhibitor of thromboxane synthetase on human blood platelet behaviour. Thromb Res 20: 219–230
Moncada S, Gryglewski RJ, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an instable substance that inhibits platelet aggregation. Nature 263: 663–665
Patrignani P, Filabuzzi P, Patrono C (1982) Selective cumulative inhibition of platelet thromboxane production by low dose of aspirin in healthy subjects. J Clin Invest 69: 1366–1372
Tyler HM (1983) Dazoxiben: A pharmacological tool or clinical candidate? Br J Clin Pharmacol 15: 13S-16S
Vermylen J, Deckmyn H (1983) Reorientation of prostaglandin endoperoxide metabolism by a thromboxane synthetase inhibitor: in vitro and clinical observations. Br J Clin Pharmacol 15: 17S-22S
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Violi, F., Ghiselli, A., Iuliano, L. et al. Inhibition by picotamide of thromboxane production in vitro and ex vivo. Eur J Clin Pharmacol 33, 599–602 (1988). https://doi.org/10.1007/BF00542494
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00542494