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Decreased peripheral β-adrenergic reactivity in asthmatics treated with oral β 2-agonists

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Summary

Peripheral β-adrenoceptor reactivity, measured as the dermal erythematous reaction to iontophoretically administered isoprenaline was studied in 41 asthmatics, 13 patients with allergic rhinoconjunctivitis and 21 healthy control subjects.

The response of intact superficial dermal blood vessels to isoprenaline, which has previously been demonstrated to be β 2-adrenoceptor mediated, was reduced in asthmatics treated with high dose, oral, slow-release β 2-agonists compared to healthy controls. The response in asthmatics not treated with oral β 2-agonists and in patients with allergic rhinoconjunctivitis did not differ from controls.

Thus, the peripheral β 2-adrenergic rectivity of intact human superficial blood vessels is affected by oral, slow-release β 2-agonists.

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References

  1. Lee T-P, Busse WMW, Reed CE (1977) Effect of betaadrenergic agonist, prostaglandins, and cortisol on lymphocyte levels of cyclic adenosine monophosphate and glycogen. J Allergy Clin Immunol 59: 408–413

    Google Scholar 

  2. Brooks SM, McGowan K, Bernstein IL, Altenau P, Peagler J (1979) Relationship between numbers of betaadrenergic receptors in lymphocytes and disease severity in asthma. J Allergy Clin Immunol 63: 401–406

    Google Scholar 

  3. Galant SP, Allred S, Griffiths R (1980) Characterization of adenylate cyclase activity in asthmatic neutrophil sonicates. Am Rev Respir Dis 122: 231–288

    Google Scholar 

  4. Galant SP, Durisetti L, Underwood S, Allred S (1980) Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma. J Clin Invest 65: 577–585

    Google Scholar 

  5. Larson K (1985) Studies of sympatho-adrenal reactivity and adrenoceptor function in bronchial asthma. Eur J Respir Dis 66 [Suppl 141]: 1–52

    Google Scholar 

  6. Juhlin L (1961) Skin reactions to iontophoretically administered epinephrine and norepinephrine in atopic dermatitis. J Invest Dermatol 37: 201–205

    Google Scholar 

  7. Harris R (1967) Therapeutic electricity and ultraviolet radiation, 2nd edn. Williams and Wilkins, Baltimore, pp 156–178

    Google Scholar 

  8. Hill JM, Gangarosa LP, Park NH (1977) Iontophoretic application of antiviral chemotherapeutic agents. Ann NY Acad Sci 284: 604–611

    Google Scholar 

  9. Gangarosa LP, Park NH, Wiggins CA, Hill JM (1980) Increased penetration of nonelectrolytes into mouse skin during iontophoretic water transport (iontohydrokinesis). J Pharmacol Exp Ther 212: 377–381

    Google Scholar 

  10. Hörnqvist R, Bäck O. Henriksson R (1984) Adrenoceptor mediated responses in human skin studied by iontophoresis. Br J Derm 3: 561–566

    Google Scholar 

  11. Hörnkvist R, Henriksson R, Bäck O (1987) Iontophoretic study of skin vessel reactivity in atopic dermatitis and its correlation to serum IgE. J Am Acad Dermatol (in press)

  12. Sandström T, Henriksson R, Hörnqvist R, Bäck O, Rosenhall L (1987) Increased peripheral α-adrenoceptor response in allergic asthmatics. Allergy (in press)

  13. Laitinen L (1974) Histamine and methacholine challenge in the testing of bronchial reactivity. Scand J Respir Dis [Suppl] 86: 1–48

    Google Scholar 

  14. Harvey JE, Baldwin CJ, Wood PJ, Alberti KGMM, Tattersfield AE (1981) Airway and metabolic responsiveness to intravenous salbutamol in asthma: Effect of regular inhaled salbutamol. Clin Sci 60: 579–585

    Google Scholar 

  15. Larsson S, Svedmyr N, Thiringer G (1977) Lack of bronchial beta-adrenoceptor resistance in asthmatics during long-term treatment with terbutaline. J Allergy Clin Immunol 59: 93–100

    Google Scholar 

  16. Fraser CM, Venter JC (1980) The synthesis of β-adrenergic receptors in cultured human lung cells: Induction by glucocorticoids. Biochem Biophys Res Commun 94: 390–397

    Google Scholar 

  17. Mano K, Akbarzadek A, Townley RG (1979) Effect of hydrocortisone on β-adrenergic receptors in lung membranes. Life Sci 25: 1925–1930

    Google Scholar 

  18. Holgate ST, Baldwin CJ, Tattersfield AE (1977) β-adrenergic agonist resistance in normal human airways. Lancet 2: 375–377

    Google Scholar 

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Authors and Affiliations

  1. Department of Lung Medicine, University Hospital of Umeå, Umeå, Sweden

    T. Sandström & L. Rosenhall

  2. Department of Histology and Oncology, University Hospital of Umeå, Umeå, Sweden

    R. Henriksson

  3. Dermatology and Venereology, University Hospital of Umeå, Umeå, Sweden

    R. Hörnkvist & O. Bäck

Authors
  1. T. Sandström
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  2. R. Henriksson
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  3. R. Hörnkvist
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  4. O. Bäck
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  5. L. Rosenhall
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Sandström, T., Henriksson, R., Hörnkvist, R. et al. Decreased peripheral β-adrenergic reactivity in asthmatics treated with oral β 2-agonists. Eur J Clin Pharmacol 33, 557–560 (1988). https://doi.org/10.1007/BF00542486

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  • DOI: https://doi.org/10.1007/BF00542486

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