European Journal of Clinical Pharmacology

, Volume 22, Issue 2, pp 181–183 | Cite as

Metergoline versus bromocriptine in the prevention of puerperal lactation

A double-blind clinical trial
  • F. Scapin
  • S. Buonaccorsi
  • G. Tronconi
  • G. Pellicciotta
  • A. E. Pontiroli


In a double blind study of the prevention of puerperal lactation, the clinical efficacy of two antiprolactin drugs was compared: metergoline 4 mg tid and bromocriptine 2.5 mg bid were both given for 7 days. An additional 7 days of treatment was administered to 16 patients in whom mammary activity was still present or appeared in the following 3 days. The first 7 day period of treatment was effective in 16/20 women receiving metergoline and in 7/20 on bromocriptine (p<0.02); the second period of treatment was effective in all remaining patients. These data indicate that metergoline acts rapidly to arrest puerperal lactation, possibly by a mechanism different from that of bromocriptine.

Key words

metergoline prolactin bromocriptine ergot alkaloids puerperal lactation anti-prolactin drugs 


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  1. 1.
    Cowie AT, Folley SJ (1970) The mammary gland and lactation. In: Philipp EE, Barnes J, Newton M (eds) Scientific foundations of obstetrics and gynecology. FA Davis Philadelphia, p 426Google Scholar
  2. 2.
    Pasteels JL, Danguy A, Frenotte M (1971) Inhibition of prolactin secretion by ergogornine and 2-Br-α-ergocriptine: direct action on hypophysis in vitro. Ann Endocrinol (Paris) 32: 188–192Google Scholar
  3. 3.
    Hokfelt T, Fuxe K (1972) Effects of prolactin and ergot alkaloids on the tubero-infundibular dopamine neurons. Neuroendocrinology 9: 100–122Google Scholar
  4. 4.
    Smythe GA (1977) The role of serotonin and dopamine in hypothalamic pituitary function. Clin Endocrinol (Oxf) 7: 325–341Google Scholar
  5. 5.
    Markin KE, Wolst MD jr (1960) A comparative controlled study of hormones used in the prevention of postpartum breast engorgement and lactation. Am J Obstet Gynecol 80: 128–137Google Scholar
  6. 6.
    Daniel DG, Campbell H, Turubull AC (1967) Puerperal thromboembolism and suppression of lactation. Lancet 2: 287–288Google Scholar
  7. 7.
    Tindall VR (1968) Factors influencing puerperal thromboembolism. Br J Obst Gynecol 75: 1324–1327Google Scholar
  8. 8.
    Delitala G, Masala A, Alagna S, Devilla L, Lodico G, Lotti G (1977) Metergoline in the inhibition of puerperal lactation. Br Med J 1: 744–746Google Scholar
  9. 9.
    Crosignani PG, Lombroso GC, Caccamo A, Reschini E, Peracchi M (1978) Suppression of puerperal lactation by metergoline. Obstet Gynecol 51: 113–115Google Scholar
  10. 10.
    Ferrari C, Reschini E, Peracchi M, Crosignani PG (1980) Endocrine profile and therapeutic employment of a new prolactin-lowering drug, metergoline. Gynecol Obstet Invest 11: 1–16Google Scholar
  11. 11.
    Varga L, Lutterbeck PM, Pryor JS, Wenner R, Erb H (1972) Suppression of puerperal lactation with an alkaloid: a double blind study. Br Med J 2: 743–745Google Scholar
  12. 12.
    Rolland P (1979) Use of bromocriptine in the inhibition of puerperal lactation. Drugs 17: 326–336Google Scholar
  13. 13.
    Parks D (1979) Drug therapy: Bromocriptine. N Engl J Med 301: 873–878Google Scholar
  14. 14.
    Sandoz Pharmaceuticals (1980) Parlodel (bromocriptine mesylate) for the prevention of physiological lactation. East Hanover, USAGoogle Scholar
  15. 15.
    Ferrari C, Caldara R, Romussi M, Rampini P, Telloli P, Zaatar S, Curtarelli G (1978) Prolactin suppression by serotonin antagonists in man: further evidence for serotoninergic control of prolactin secretion. Neuroendocrinology 25: 319–328Google Scholar
  16. 16.
    Perez-Lopez FR, Delvoje P, Denayer P, L'Hermite M, Roncerro MC, Robyn C (1975) Effect of methylergobasine maleate on serum gonadotrophin and prolactin in humans. Acta Endocrinol 79: 644–657Google Scholar
  17. 17.
    Pontiroli AE, Alberetto M, Pellicciotta G, Da Castro e Silva E, De Sasqua A, Girardi AM, Pozza G (1980) Interaction of dopaminergic and antiserotoninergic drugs in the control of prolactin and LH release in normal women. Acta Endocrinol 93: 271–276Google Scholar
  18. 18.
    Nader S, Kjeld JM, Blair CM, Tooley P, Gordon H, Fraser TR (1975) A study of the effect of bromocriptine on serum estradiol, prolactin and follicle stimulating hormone levels in puerperal women. Br J Obstet Gynecol 82: 750–755Google Scholar
  19. 19.
    Falsetti L, Voltolini AM, Pollini C, Pontiroli AE (1979) A study on prolactin, FSH and LH in puerperium: spontaneos variations and effect of metergoline. Proceedings of Symp. on Central and Peripheral Regulation of Prolactin Function. Taormina (Italy), p 89Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • F. Scapin
    • 1
    • 2
  • S. Buonaccorsi
    • 1
    • 2
  • G. Tronconi
    • 1
    • 2
  • G. Pellicciotta
    • 1
    • 2
  • A. E. Pontiroli
    • 1
    • 2
  1. 1.Istituto Regina ElenaMilanoItaly
  2. 2.Clinica Medica 8Università di Milano, Ospedale San RaffaeleMilanoItaly

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