Summary
16 premature infants suffering from neonatal apnoea received orally an aqueous solution of theophylline 5 mg/kg bodyweight under fasting conditions and immediately before a milk feed. Bioavailability up to 7 h after administration was determined from the serum concentration-time course. The rate of absorption was significantly decreased if the drug was given with food; mean maximum serum concentrations were reached after 4.7 h instead of 1.6 h under fasting conditions. The area under the curve did not differ between the two patient groups which indicates that only the rate but not the amount of absorption was affected by food intake. The influence of feeding on the rate of absorption of theophylline by premature infants, which is more pronounced than in adults, can be related to particular functional factors in the gastrointestinal tract during the neonatal period.
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References
Aranda JV, Sitar DS, Parsons WD, Loughnan PM, Neims AH (1976) Pharmacokinetic aspects of theophylline in premature newborns. N Engl J Med 295: 413–416
Brazier JL, Renaud H, Ribon B, Fancon G, Sassard J (1978) Evolution du taux plasmatique des xanthines dans le traitement de l'apnee du premature. Therapie 33: 341–355
Dost FH (1968) Grundlagen der Pharmakokinetik. G. Thieme, Stuttgart
Giacoia G, Jusko WJ, Menke J, Koup JR (1976) Theophylline pharmacokinetics in premature infants with apnea J Pediatr 89: 829–832
Green ER, Green AW, Laue R, Slaugther R, Middleton jr E (1981) Absorption characteristics of sustained release theophylline capsules administered in applesauce. J Pediatr 5: 832–834
Gushaw JB, Hu MW, Singh P, Miller JG, Schneider RS (1977) Homogenous enzyme immunoassay for theophylline in serum. Clin Chem 23: 1144
von Hattingberg HM, Brockmeier D, Kreuter G (1977) A rotating iterative procedure (RIP) for estimation hybrid constants in multi-compartment analysis on desk computers. Eur J Clin Pharmacol 11: 381–388
Heimann G (1980) Enteral absorption and bioavailability in children in relation to age. Eur J Clin Pharmacol 18: 43–50
Hilligoss DM, Jusko WJ, Koup JR, Giacoia G (1980) Factors affecting theophylline pharmacokinetics in premature infants with apnea. Dev Pharmacol Ther 1: 6–15
Jones RAK, Baillie E (1979) Dosage schedule for intravenous aminophylline in apnea of prematurity, based on pharmacokinetic studies. Arch Dis Child 54: 190–193
Langercrantz H, Rane A, Tunell R (1980) Plasma concentration-effect relationship of theophylline in treatment of apnea in preterm infants. Eur J Clin Pharmacol 18: 65–68
Latini R, Assael BM, Bonati M, Caccomo ML, Gerna M, Mandelli M, Marini A, Sereni F, Tognoni G (1978) Kinetics and efficacy of theophylline in the treatment of apnea in the premature newborn Eur J Clin Pharmacol 13: 203–207
Russel CJ, Elwood RK, Kinney C, McDewitt DG (1980) Plasma theophylline concentrations following the oral administration of microcrystalline theophylline and a new sustained-release theophylline preparation to normal subjects. Eur J Clin Pharmacol 18: 351–354
Upton RA, Sansom L, Guentert TW, Powell JR, Shah VP, Coates PE, Riegelman S (1980) Evaluation of the absorption from 15 commercial theophylline products indicating deficiencies in currently applied bioavailability criteria. J Pharmacokinet Biopharm 3: 229–242
Weinberger M (1978) Theophylline for treatment of asthma. J Pediatr 92: 1
Welling PG, Lyons LL, Craig WA, Trochta GA (1975) Influence of diet and fluid on bioavailability of theophylline. Clin Pharmacol Ther 4: 475–480
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Part of the doctoral thesis of J. Murgescu is included in this study
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Heimann, G., Murgescu, J. & Bergt, U. Influence of food intake on bioavailability of theophylline in premature infants. Eur J Clin Pharmacol 22, 171–173 (1982). https://doi.org/10.1007/BF00542463
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DOI: https://doi.org/10.1007/BF00542463