European Journal of Clinical Pharmacology

, Volume 30, Issue 5, pp 635–636 | Cite as

Diurnal variation in the pharmacokinetics of intravenous theophylline and etophylline in healthy subjects

  • B. L. Chauhan
  • B. S. Doshi
  • R. D. Kulkarni
Letters To The Editors

Key words

theophylline etophylline diurnal variations i.v. application pharmacokinetics 


  1. 1.
    Kyle GN, Smolensky MH, Thorne LG, Gahsi BP, Robinson A, McGoverern JP (1980) Circadian rhythm in the pharmacokinetics of orally administered Theophylline. In: Recent advances in the chronobiology of allergy and Immunology. Pergamon Press, Oxford, p 95–111Google Scholar
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    Lesko LJ, Broussean D, Canada AT, Eastwood G (1980) Temporal variations in serum theophylline concentrations at steadystate. J Pharm Sci 69: 358–359Google Scholar
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    Wood JH, Garrettson LK (1983) An explanation of circadian rhythm for theophylline and other drugs. Lancet 2: 570Google Scholar
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    Ocrutt JJ, Kozak PP, Gilmann SA, Cummius LH (1977) Microscale method for theophylline in body fluids by reversed phase high pressure liquid chromatography. Clin Chem 23: 124–127Google Scholar
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    Gundert-Remy U, Hilderbrandt R, Hengen H, Weber E (1983) Non-linear elimination process of Theophylline. Eur J Clin Pharmacol 13: 567–568Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • B. L. Chauhan
    • 1
  • B. S. Doshi
    • 1
  • R. D. Kulkarni
    • 1
  1. 1.Department of PharmacologyGrant Medical CollegeBombayIndia

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