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European Journal of Clinical Pharmacology

, Volume 32, Issue 2, pp 217–218 | Cite as

Concentrations of ciprofloxacin in human liver, gallbladder, and bile after oral administration

  • M. Dan
  • N. Verbin
  • A. Gorea
  • H. Nagar
  • S. A. Berger
Short Communications

Summary

We have measured concentrations of ciprofloxacin in serum, hepatic tissue, gallbladder, and bile in 10 patients after a single oral dose of 750 mg given before cholecystectomy. Mean liver and gallbladder tissue concentrations were 12.76 µg·g−7±2.79 (SEM) and 5.94 µg·g−1±1.35, respectively. Concentrations in bile taken from the gallbladder (7 patients) ranged from 68 to 225 µg·ml−1, with a mean bile/serum concentration ratio of 49. Concentrations in bile taken from the common bile duct (2 patients) were 17 and 16 µg·ml−1.

Key words

ciprofloxacin cholecystitis bile 

References

  1. 1.
    Brogard JM, Jehl F, Monteil H, Adloff M, Blickle JF, Levy P (1985) Comparison of high-pressure liquid chromatography and microbiological assay for the determination of biliary elimination of ciprofloxacin in humans. Antimicrob Agents Chemother 28: 311–314Google Scholar
  2. 2.
    Chin N, Neu HC (1984) Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 25: 319–326Google Scholar
  3. 3.
    Wacha H, Helm EB (1982) Efficacy of antibiotics in bacterobilia. J Antimicrob Chemother 9 [Suppl A]: 131–137Google Scholar
  4. 4.
    Wolfson JS, Hooper DC (1985) The fluoroquinolones: Structures, mechanism of action and resistance, and spectrum of activity in-vitro. Antimicrob Agents Chemother 28: 581–586Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • M. Dan
    • 1
  • N. Verbin
    • 2
  • A. Gorea
    • 3
  • H. Nagar
    • 2
  • S. A. Berger
    • 3
  1. 1.Infectious Diseases UnitUniversity of Tel-AvivTel-AvivIsrael
  2. 2.Department of SurgeryUniversity of Tel-AvivTel-AvivIsrael
  3. 3.Department of Microbiology, The Tel-Aviv Medical Center, and The Sackler School of MedicineUniversity of Tel-AvivTel-AvivIsrael

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