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Variability of plasma drug concentrations: Some observations

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References

  1. Dayer P, Balant L, Küpfer F, Courvoisier F, Fabre J (1983) Contribution of the genetic status of oxidative metabolism to variability in the plasma concentrations of beta-adrenoceptor blocking agents. Eur J Clin Pharmacol 24: 797–799

    Google Scholar 

  2. Idle JR, Sever PS (1983) Treatment of angina pectoris with nifedipine. Br Med J 286: 1978–1979

    Google Scholar 

  3. Idle JR, Oates NS, Shah RR, Smith RL (1983) Protecting poor metabolisers, a group at high risk of adverse drug reactions. Lancet 1: 1388

    Google Scholar 

  4. Jack DB, Quarterman CP, Zaman R, Kendall MJ (1982) Variability of beta-blocker pharmacokinetics in young volunteers. Eur J Clin Pharmacol 23: 37–42

    Google Scholar 

  5. Jack DB, Wilkins MR, Quarterman CP (1983) Lack of evidence for polymorphism in metoprolol metabolism. Br J Clin Pharmacol 16: 188–190

    Google Scholar 

  6. Lennard MS, Silas JH, Freestone S, Ramsay LE, Tucker GT, Woods HF (1982) Oxidation phenotype — a major determinant of metoprolol metabolism and response. N Engl J Med 307: 1558–1560

    Google Scholar 

  7. Lennard MS, Ramsay LE, Silas JH, Tucker GT, Woods HF (1983) Protecting the poor metaboliser: Clinical consequences of genetic polymorphism of drug oxidation. Pharm Int 4: 53–57

    Google Scholar 

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Authors and Affiliations

  1. Department of Therapeutics and Clinical Pharmacology The Medical School Edgbaston, The University of Birmingham, B15 2TJ, Birmingham, England

    D. B. Jack

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  1. D. B. Jack
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  2. M. R. Wilkins
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  3. M. J. Kendall
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  4. P. E. Hall
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Jack, D.B., Wilkins, M.R., Kendall, M.J. et al. Variability of plasma drug concentrations: Some observations. Eur J Clin Pharmacol 25, 569–570 (1983). https://doi.org/10.1007/BF00542131

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  • DOI: https://doi.org/10.1007/BF00542131

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