European Journal of Clinical Pharmacology

, Volume 25, Issue 4, pp 567–568 | Cite as

Lack of effect of astemizole on ethanol dynamics or kinetics

  • D. N. Bateman
  • P. H. Chapman
  • M. D. Rawlins
Short Communication


The effects of astemizole (10 mg daily for 7 days) on the kinetics and CNS depressant activity of ethanol have been examined in a double-blind cross-over study agonist placebo in 7 volunteers. There was no significant change in the elimination rate or AUC of the plasma ethanol concentration-time curve after astemizole. Central nervous system effects of ethanol as monitored by visual analogues of sedation, visual discrimination, pursuit rotor and reaction time were also unaffected by astemizole pretreatment.

Key words

astemizole ethanol antihistamine pharmacodynamics pharmacokinetics 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • D. N. Bateman
    • 1
  • P. H. Chapman
    • 1
  • M. D. Rawlins
    • 1
  1. 1.Wolfson Unit of Clinical PharmacologyUniversity of Newcastle upon TyneEngland

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