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European Journal of Clinical Pharmacology

, Volume 25, Issue 4, pp 567–568 | Cite as

Lack of effect of astemizole on ethanol dynamics or kinetics

  • D. N. Bateman
  • P. H. Chapman
  • M. D. Rawlins
Short Communication

Summary

The effects of astemizole (10 mg daily for 7 days) on the kinetics and CNS depressant activity of ethanol have been examined in a double-blind cross-over study agonist placebo in 7 volunteers. There was no significant change in the elimination rate or AUC of the plasma ethanol concentration-time curve after astemizole. Central nervous system effects of ethanol as monitored by visual analogues of sedation, visual discrimination, pursuit rotor and reaction time were also unaffected by astemizole pretreatment.

Key words

astemizole ethanol antihistamine pharmacodynamics pharmacokinetics 

References

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    Chapman PH, Rawlins MD (1983) A comparison of astemizole and chlorpheniramine in normal volunteers. (Submitted for publication)Google Scholar
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    Feely J, Wood AJJ (1982) Effects of cimetidine on the elimination and action of ethanol. J Am Med Assoc 247: 2819–2821Google Scholar
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    Lieber CS, De Carli LM (1970) Hepatic microsomal ethanoloxidating system. In vitro characteristics and adaptive properties in vivo. J Biol Chem 1970: 245-2505-12Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • D. N. Bateman
    • 1
  • P. H. Chapman
    • 1
  • M. D. Rawlins
    • 1
  1. 1.Wolfson Unit of Clinical PharmacologyUniversity of Newcastle upon TyneEngland

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