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European Journal of Clinical Pharmacology

, Volume 25, Issue 4, pp 459–462 | Cite as

Relative immunosuppressive potency of various corticosteroids measured in vitro

  • E. Langhoff
  • J. Ladefoged
Originals

Summary

Natural and synthetic steroids and mineralocorticoids were tested for their in vitro suppressive activity on phytohemagglutinin (PHA) stimulated lymphocytes. Three different (p<0.05) groups were identified. Methylprednisolone and betamethasone were very potent, dexamethasone, hydrocortisone and prednisolone were of intermediate potency, and aldosterone, prednisone and the metabolites of hydrocortisone were of low potency. In general, synthetic steroids were considerably more potent than naturally occurring compounds, but the relatively low potency of dexamethasone was unexpected. These in vitro findings rank glucocorticoid potency differently from the relative anti-inflammatory activities reported in the literature.

Key words

glucocorticoids lymphocyte transformation PHA stimulation anti-inflammatory potency immunosuppressive potency hydrocortisone methylprednisolone betamethasone dexamethasone prednisolone aldosterone prednisone 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • E. Langhoff
    • 1
  • J. Ladefoged
    • 1
  1. 1.Medical Department P, Division of NephrologyRigshospitaletCopenhagenDenmark

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