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Family study of genetic and environmental factors determining the protein binding of propranolol

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Summary

The unbound fraction of propranolol was found to vary from 1.9 to 13.2% in 434 plasma samples from members of 132 families. As expected, there was a linear correlation between the ratio of bound/unbound propranolol and the orosomucoid concentration (r=0.67, P<0.001). Albumin concentration did not influence propranolol binding. The unbound fraction was negatively correlated with obesity and alcohol intake, but was not significantly influenced by age and sex. By applying path analysis, 21% of the variability in propranolol binding could be ascribed to genetic factors and 5% to common environmental factors.

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Author notes

  1. O. Borgå

    Present address: AB Draco, Box 1707, S-221-01, Lund, Sweden

Authors and Affiliations

  1. Department of Clinical Pharmacology, Huddinge University Hospital, Sweden

    G. Alván, K. Bergström, O. Borgå, L. Iselius & N. Pedersen

  2. Departments of Clinical Genetics and Clinical Chemistry, Karolinska Hospital, Sweden

    G. Alván, K. Bergström, O. Borgå, L. Iselius & N. Pedersen

  3. Department of Environmental Hygiene, Karolinska Institute, Stockholm, Sweden

    G. Alván, K. Bergström, O. Borgå, L. Iselius & N. Pedersen

  4. Population Genetics Laboratory, University of Hawaii, Honolulu, Hawaii, USA

    G. Alván, K. Bergström, O. Borgå, L. Iselius & N. Pedersen

Authors
  1. G. Alván
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  2. K. Bergström
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  3. O. Borgå
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  4. L. Iselius
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  5. N. Pedersen
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Alván, G., Bergström, K., Borgå, O. et al. Family study of genetic and environmental factors determining the protein binding of propranolol. Eur J Clin Pharmacol 25, 437–441 (1983). https://doi.org/10.1007/BF00542107

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  • DOI: https://doi.org/10.1007/BF00542107

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