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European Journal of Clinical Pharmacology

, Volume 20, Issue 6, pp 435–441 | Cite as

Measurement of excretion characteristics of theophylline and its major metabolites

  • J. H. G. Jonkman
  • D. Tang
  • R. A. Upton
  • S. Riegelman
Originals

Summary

Analysis of urinary excretion after administration of 320 mg of theophylline to six normal volunteers appears to indicate the occurrence of capacity limited formation of most of the theophylline metabolites and non-linear renal excretion of theophylline. The renal clearance is elevated at high concentrations where the metabolic clearance is reduced. Even though the individual process of elimination is non-linear, the compensating relationship appears to yield a constant total elimination clearance. The implication of these results in chronic therapy and dose adjustment is discussed.

Key words

theophylline renal excretion metabolite formation capacity-limited kinetics 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. H. G. Jonkman
    • 1
  • D. Tang
    • 1
  • R. A. Upton
    • 1
  • S. Riegelman
    • 1
  1. 1.School of Pharmacy, Department of PharmacyUniversity of CaliforniaSan FranciscoUSA

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