European Journal of Clinical Pharmacology

, Volume 21, Issue 6, pp 517–520 | Cite as

A pharmacokinetic study of mianserin

  • K. P. Maguire
  • T. R. Norman
  • G. D. Burrows
  • B. A. Scoggins
Originals

Summary

The kinetics of mianserin have been evaluated in eight healthy male volunteers following a single oral dose of 60 mg. Plasma and blood concentrations of mianserin were measured by gas chromatography-mass fragmentography. The peak blood concentration observed was 65 µg/l at 3 h following the dose. Mean kinetic parameters (and range) calculated from the blood concentrations were: (t1/2)abs 1.1 h (0.3–2.8), (t1/2)α 2.5 h (0.9–4.7), (t1/2)β 21 h (14–33), (Vd)β 27.5 l/kg (16.8–46.5) and Cloral 0.98 l/kg/h (0.47–1.75). Blood/plasma concentration ratios ranged from 0.50–0.74.

Key words

mianserin blood plasma oral kinetic parameters healthy volunteers 

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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • K. P. Maguire
    • 1
  • T. R. Norman
    • 1
  • G. D. Burrows
    • 1
  • B. A. Scoggins
    • 2
  1. 1.Department of PsychiatryUniversity of MelbourneAustralia
  2. 2.Howard Florey Institute of Experimental Physiology and MedicineUniversity of MelbourneAustralia

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