Abstract
When regional intraarterial infusion is applied in the treatment of malignant tumors it is essential to reach the tumor via all its major feeder vessels. In this study VX-2 carcinoma was implanted into the lower pole of the left kidney in 24 rabbits to investigate whether the renal capsular artery takes part in tumor feeding. The rabbits were divided into four groups that were followed for 8, 10, 12 or 14 days after tumor implantation. At that time the renal artery was ligated close to the kidney and subsequently silicone rubber or barium sulfate/gelatin suspension was injected into the capsular artery. The tissue was cleared, and the tumor carefully removed and examined microscopically for traces of silicone rubber. When barium sulfate had been injected, the kidney was examined radiographically in order to detect possible presence of contrast medium in the tumor. This study revealed no vascular supply to the implanted VX-2 carcinoma from the capsular artery when the tumor was confined intracapsularly, i.e., up to 12 days after tumor implantation in untreated rabbits.
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Baranyai T, Vargha G, Gyarmati J, Harkányi Z (1988) Experimentelle (in vivo und in vitro) Ultrasonographie von Vx2 Nierenkarzinomen. Radiol Diagn (Berl) 29:835
Boijsen E, Folin J (1961) Angiography in the diagnosis of renal carcinoma. Radiologe 1:173
Gadeholt G, Göthlin JH (1987) Intraarterial doxorubicin infusion treatment with and without occlusion of the renal artery in rabbit renal VX-2 carcinoma. Establishing an animal model. Acta Radiol 28:467
Göthlin JH, Barbaric ZL (1978) Tissue adhesive in surgical and crush renal trauma. An experimental angiographic investigation in the rabbit. Scand J Urol Nephrol 12:145
Meyers MA, Friedenberg RM, King MC, Meng CH (1967) The significance of the renal capsular arteries. Br J Radiol 40:949
Sträuli P, Haemmerli G (1984) The V2 carcinoma of the rabbit as an integrated model of tumor invasion. Bull Cancer (Paris) 71:447
Vargha G (ed) (1981) Pharmacoangiography of the kidney, chapter 2. In: Pharmacoangiography in the diagnosis of tumours. Akadémiai Kiadó, Budapest
Vargha G, Miltényi L, Endes J, Endes P, Kelemen J, Szücs L (1974) Über eine neue Transplantationsmethode des Vx2-Nierencarcinoms von Kaninchen. Res Exp Med 164:77
Vargha G, Miltényi L, Endes J, Kelemen J (1977) Urografische Bewertung des VX2-Nierenkarzinoms und der Kontroll-Implantation bei Kaninchen. Acta Chir Hung 18:193
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Gadeholt-Göthlin, G., Göthlin, J.H. Relationship between renal capsular artery feeding and size of VX-2 carcinoma implant in the rabbit kidney. Urol. Res. 22, 231–234 (1994). https://doi.org/10.1007/BF00541898
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DOI: https://doi.org/10.1007/BF00541898