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Pharmacokinetic parameters of bevantolol in volunteers

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Summary

The pharmacokinetics of the new beta-adrenoceptor blocking drug bevantolol and some aspects of its beta-blocking effect have been studied in healthy volunteers. Bevantolol had a short serum half-life (86±33 min) and high systemic availability after oral administration. The observed changes in heart rate, systolic blood pressure during excercise and plasma renin activity were all compatible with beta-adrenoceptor blockade. After 200 mg p.o. in the morning, the effects lasted for less than 24 h.

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Authors and Affiliations

  1. Departments of Hospital Pharmacy and Toxicology, University Hospital, Leiden, The Netherlands

    P. Vermeij

  2. Department of Nephrology, University Hospital, Leiden, The Netherlands

    P. van Brummelen

Authors
  1. P. Vermeij
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  2. P. van Brummelen
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Vermeij, P., van Brummelen, P. Pharmacokinetic parameters of bevantolol in volunteers. Eur J Clin Pharmacol 30, 375–377 (1986). https://doi.org/10.1007/BF00541549

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  • DOI: https://doi.org/10.1007/BF00541549

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