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European Journal of Clinical Pharmacology

, Volume 30, Issue 3, pp 269–271 | Cite as

Increased effect of multiple doses of 40 749 RP a new long acting gastric antisecretory agent

  • J. Forichon
  • Y. Minaire
  • C. Barthélémy
  • R. Woehrlé
  • J. Simon
Originals

Summary

40 749 RP, a pyridyl-2-tetrahydrothiophene derivative is known to be a potent gastric antisecretory agent in animals and man. In 27 healthy volunteers in four double-blind cross-over studies, this activity has been examined against basal and pentagastrin stimulated gastric acid secretion. The effect of a single oral dose of 2 mg/kg was still present after 12, 24 and 48 h. The effect of 1 mg/kg was definitely increased after treatment for 7 days as compared to a single dose of 1 mg/kg.

Key words

gastric antisecretory agent 40 749 RP long acting drug healthy volunteers 

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References

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Forichon
    • 1
  • Y. Minaire
    • 1
  • C. Barthélémy
    • 2
  • R. Woehrlé
    • 3
  • J. Simon
    • 3
  1. 1.INSERM U 45, Hôpital E. HerriotLyonFrance
  2. 2.Hôpital Nord, Saint Priest en JarezFrance
  3. 3.Rhône-Poulenc SanteCourbevoieFrance

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