Rheumatology International

, Volume 5, Issue 4, pp 155–161 | Cite as

Spontaneous and aggregated IgG induced rheumatoid factor producing cells in rheumatoid arthritis

  • E. J. Pisko
  • R. A. Turner
  • M. Panetti
  • S. L. Foster
  • E. Heise


Seropositive rheumatoid arthritis (RA) patients were found to have high numbers of spontaneously occurring cells making rheumatoid factor (RF) reactive with human IgG as measured by a RF plaque forming cell (RF-PFC) assay. There was a significant positive correlation between the number of RF-PFC and both disease activity measured by the sedimentation rate and RF titer measured by the RA latex test. Aggregated IgG and pokeweed mitogen were equally effective stimulators of RF-PFC in cultures of RA peripheral blood mononuclear leukocytes. The rheumatoid ratio of helper (T4): suppressor (T8) T lymphocytes was also significantly increased over the ratio of normal controls, but this ratio did not correlate with the number of RF-PFC. Aggregated IgG or immune complexes may be responsible for stimulating RA RF-PFC in vivo.

Key words

Rheumatoid arthritis Rheumatoid factor Helper: Suppressor T lymphocytes Immune complexes 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • E. J. Pisko
    • 1
  • R. A. Turner
    • 1
  • M. Panetti
    • 1
  • S. L. Foster
    • 1
  • E. Heise
    • 2
  1. 1.Section on Rheumatology, Department of MedicineBowman Gray School of Medicine of Wake Forest UniversityWinston-SalemUSA
  2. 2.Department of Microbiology/ImmunologyBowman Gray School of Medicine of Wake Forest UniversityWinston-SalemUSA

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