Rheumatology International

, Volume 5, Issue 5, pp 209–214 | Cite as

Rheumatoid factors in rheumatoid arthritis and vasculitis

  • M. L. Westedt
  • P. Herbrink
  • J. L. Molenaar
  • E. de Vries
  • P. Verlaan
  • T. Stijnen
  • A. Cats
  • J. Lindeman
Originals

Summary

To study the occurrence of rheumatoid factors (RF) in relation to the activity of rheumatoid arthritis and the occurrence of vasculitis, RF of IgM, IgA, and IgG classes were measured in sera from 35 patients with definite or classic rheumatoid arthritis (RA) using ELISA. For 26 patients, the RF levels were studied longitudinally and compared with changes in the articular index. Although IgM RF was occasionally found in patients without RA, IgA and/or IgG RF were almost exclusively associated with RA. The titers of IgM, IgA, and IgG RF were significantly higher in sera from patients with clinically diagnosed rheumatoid vasculitis than in sera from patients without vasculitis. No significant correlation between changes in the articular index and changes in titer of any class-specific RF could be found for the group of RA patients as a whole. However, in individual patients, increases or decreases in IgM and IgG RF titer were significantly correlated with an increase or decrease in the articular index.

Key words

Rheumatoid factors ELISA Vasculitis 

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References

  1. 1.
    Valkenburg HA (1963) Human erythrocyte agglutination test [HEAT]. In: Kellgren JH, Jeffrey MR, Ball J (eds) The epidemiology of chronic rheumatism, vol I. Blackwell, Oxford, p 330Google Scholar
  2. 2.
    Klein F, Bronsveld W, Norde W, Romunde LKJ van, Singer JM (1979) A modified latex-fixation test for the detection of rheumatoid factors. J Clin Pathol 32:90–92Google Scholar
  3. 3.
    Faith A, Pontesilli O, Unger A, Panayi GS, Johns P (1982) ELISA assays for IgM and IgG rheumatoid factors. J Immunol 55:169–177Google Scholar
  4. 4.
    Nishimaki T, Watanabe S, Yoshida H, Kasukawa (1983) Immunoglobulin class of rheumatoid factors detected by enzyme-linked immunosorbent assay. Clin Rheumatol 2:145–151Google Scholar
  5. 5.
    Estes D, Atra E, Peltier A (1973) An immunofluorescent method for the detection of antigammaglobulin antibodies. Arthritis Rheum 16:59–65Google Scholar
  6. 6.
    Kallerup HE, Egeskjold EM, Grandal H (1979) IgG, IgM and IgA rheumatoid factors in healthy adults and rheumatoid patients determined by an indirect immunofluorescent method. Scand J Rheumatol 8:1–9Google Scholar
  7. 7.
    Pope RM, McDuffy SJ (1979) IgG rheumatoid factor: relationship to seropositive rheumatoid arthritis and absence in seronegative disorders. Arthritis Rheum 22:988–998Google Scholar
  8. 8.
    Carson DA, Lawrence S, Catalano MA, Vaugham JH, Abraham G (1977) Radioimmuno assay of IgG and IgM rheumatoid factors reacting with human IgG. J Immunol 119:295–300Google Scholar
  9. 9.
    Quismorio FP, Beardmore T, Kaufman RL, Mongan ES (1983) IgG rheumatoid factors and anti-nuclear antibodies in rheumatoid vasculitis. Clin Exp Immunol 52:333–340Google Scholar
  10. 10.
    Theofilopoulos A, Burtonboy G, Lopalluto JJ, Ziff M (1974) IgG rheumatoid factor and low molecular weight IgM. Arthritis Rheum 17:272–284Google Scholar
  11. 11.
    Winchester RJ, Agnello V, Kunkel HG (1970) Gammoglobulin complexes in synovial fluids of patients with rheumatoid arthritis: partial characterization and relationship to lowered complement levels. Clin Exp Immunol 6:689–706Google Scholar
  12. 12.
    Teitsson J, Withrington RH, Leifert MH, Valdimarsson H (1984) Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor. Ann Rheum Dis 43:673–678Google Scholar
  13. 13.
    Ropes MW, Bennet GA, Cobb S, Jacox R, Jessar RA (1958) Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175–176Google Scholar
  14. 14.
    Ritchie DM, Boyle JA, McInnes JM, Jasani JM, Dalcos TG, Grieveson P, Buchanan WW (1986) Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis. Q J Med 37:393–398Google Scholar
  15. 15.
    Heymans W, Schmitt HRE, Klein F (1969) An immunofluorescence procedure for the detection of intracellular immunoglobulins. Clin Exp Immunol 4:457–472Google Scholar
  16. 16.
    Tarkowski A, Bjunslen LH, Nilsson LA, Nygren H (1983) False positive results in class-specific rheumatoid factor (RF) assays due to interaction between RF and Fc fragments of anti-immunoglobulin indicator reagents. J Immunol Methods 58:171–182Google Scholar
  17. 17.
    Lessard J, Nummery E, Cecerei F, McDuffy S, Pope RM (1984) Relationship between the articular manifestations of rheumatoid arthritis and circulating immune complexes detected by three methods and specific classes of rheumatoid factors. J Rheumatol 10:411–417Google Scholar
  18. 18.
    Westedt ML, Mayer CJLM, Vermeer J, Cats A, Vries E de (1984) Rheumatoid arthritis — the clinical significance of histo- and immuno-pathological abnormalities in normal skin. J Rheumatol 11:448–453Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • M. L. Westedt
    • 1
  • P. Herbrink
    • 2
  • J. L. Molenaar
    • 2
  • E. de Vries
    • 2
  • P. Verlaan
    • 2
  • T. Stijnen
    • 3
  • A. Cats
    • 1
  • J. Lindeman
    • 2
  1. 1.Department of RheumatologyUniversity HospitalLeidenThe Netherlands
  2. 2.Department of Clinical ImmunologySSDZDelftThe Netherlands
  3. 3.Department of Medical StatisticsUniversity of LeidenLeidenThe Netherlands

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