Rheumatology International

, Volume 9, Issue 6, pp 259–264 | Cite as

Absence of correlations between indices of systemic inflammation and synovial fluid interleukin 1 (alpha and beta) in rheumatic diseases

  • F. S. di Giovine
  • S. Poole
  • R. D. Situnayake
  • M. Wadhwa
  • G. W. Duff
Originals

Summary

There are two forms of the cytokine interleukin 1 (IL1), produced by two distinct genes encoding a neutral (IL1 beta) and an acidic (IL1 alpha) peptide. They have powerful pro-inflammatory, immunopotentiating, catabolic and arthritogenic properties in vivo and have been implicated in the pathogenesis of rheumatic diseases. In this study, using specific immunoassays, we have measured both IL1 alpha and IL1 beta levels in synovial fluids (SF) from a large number of patients with different rheumatic diseases. Biologically significant levels of both cytokines were found in SF from patients with different forms of arthritis, but no correlations were found with any of the measures of disease activity that we tested. We also describe the presence in joint exudates of biological inhibitor(s) that neutralize IL1-induced T-cell activation. This is the first report of IL1 alpha and IL1 beta measurements in the same synovial exudates and also of the comparison of local levels of these cytokines with conventional indices of systemic inflammation.

Key words

Arthritis Synovial fluids Interleukin 1 IL1 alpha IL1 beta Biological inhibitors 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • F. S. di Giovine
    • 1
  • S. Poole
    • 2
  • R. D. Situnayake
    • 1
  • M. Wadhwa
    • 2
  • G. W. Duff
    • 1
  1. 1.Department of Medicine, Rheumatic Diseases UnitUniversity of Edinburgh, Northern General HospitalEdinburghUK
  2. 2.National Institute for Biological Standards and ControlPotters BarUK

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