European Journal of Clinical Pharmacology

, Volume 31, Issue 6, pp 729–731 | Cite as

Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times

  • S. E. Tett
  • D. J. Cutler
Short Communications


We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity.

Key words

chloroquine pharmacokinetics dose-dependence exponential equations 


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • S. E. Tett
    • 1
  • D. J. Cutler
    • 1
  1. 1.Department of PharmacyThe University of SydnyeSydneyAustralia

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