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Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times

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Summary

We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity.

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Authors and Affiliations

  1. Department of Pharmacy, The University of Sydnye, Sydney, Australia

    S. E. Tett & D. J. Cutler

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  1. S. E. Tett
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  2. D. J. Cutler
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Tett, S.E., Cutler, D.J. Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times. Eur J Clin Pharmacol 31, 729–731 (1987). https://doi.org/10.1007/BF00541305

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  • DOI: https://doi.org/10.1007/BF00541305

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