Rheumatology International

, Volume 4, Supplement 1, pp 25–30 | Cite as

Disease susceptibility genes and the Ia system

  • J. Silver


Certain Ia allotypes such as DR4 show a strong association with particular autoimmune diseases such as rheumatoid arthritis. Despite this strong association, a significant number of individuals whith the inappropriate Ia allotype develop the disease. It is proposed that these individuals share an Ia determinant or “epitope” with individuals of the appropriate Ia allotype, and that these epitopes, which are “mobile” and can be transmitted from one Ia haplotype and/or gene locus to another by mechanisms such as gene conversion, form the molecular basis for disease-susceptibility genes.

Key words

Ia genes Polymorphism Disease susceptibility Shared epitopes Gene conversion 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • J. Silver
    • 1
  1. 1.The Cellular and Molecular Biology UnitThe Hospital for Joint DiseasesNew YorkUSA

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