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HLA-B27 in possible ankylosing spondylitis with peripheral arthritis

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Summary

Among 86 patients selected as possibly having ankylosing spondylitis because of clinical symptoms and radiologically normal sacroiliac joints, HLA-B27 was positive in 41%. Four years later a representative sample of 38 individuals were re-examined and radiographed. HLA-B27 positive patients developed sacroiliitis as defined by radiological criteria twice as often (P<0.05). They also showed increased uptake of technetium 99 m upon quantitative scintigraphy with a region of interest method and more often probable or definite ankylosing spondylitis as defined by the New York criteria. Further differences between the HLA-B27 positive and negative follow-up groups concerned the frequency of clinical symptoms and peripheral arthritis. It is suggested that HLA-B27 typing may be helpful both in diagnosis and in judging the prognosis of possible or abortive ankylosing spondylitis.

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References

  1. Brewerton DA, Caffrey M, Hart FD, James DCO, Nicholls A, Sturrock RD (1973) Ankylosing spondylitis and HLA 27. Lancet I:904–907

    Google Scholar 

  2. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM (1973) High association of HL'A antigen W27, with ankylosing spondylitis. N Engl J Med 288:704–706

    Google Scholar 

  3. Moll JHM, Haslock J, Macrde J, Wright V (1974) Associations between ankylosing spondylitis, psoriatic arthritis, Reiter's disease, the intestinal arthropathies and Behçets syndrome. Medicine 53:343–364

    Google Scholar 

  4. Brewerton DA, James DCO (1975) The histocompatibility antigen (HL-A27) and disease. Semin Arthritis Rheum 4:191–207

    Google Scholar 

  5. Calin A, Porta J, Fries JF, Schurman DJ (1977) Clinical history as a screening test for ankylosing spondylitis. JAMA 237:2613–2614

    Google Scholar 

  6. Gerber N, Ambrosini GC, Böni A, Ossola A, Wagenhäuser FJ, Fehr K, v. Felten A (1977) Spondylitis ankylosans (M. Bechterew) und Gewebsantigen HLA-B27. I. Diagnostische Aussagekraft der HLA-Typisierung. Z Rheumatol 36:219–223

    Google Scholar 

  7. Esdaile JM, Dwash JL, Urowitz MB, Smythe HA, Falk J (1977) HLA-B27 in rheumatoid factor negative polyarthritis. Ann Intern Med 86:699–702

    Google Scholar 

  8. Golding DN, Jenkins WJ (1974) Histocompatibility testing in doubtful cases of ankylosing spondylitis. Lancet II:522–523

    Google Scholar 

  9. Hill HF, Hill AG, Bodmer JG (1976) Clinical diagnosis of ankylosing spondylitis in women and relation to presence of HLA-B27. Ann Rheum Dis 35:267–270

    Google Scholar 

  10. Tausch G, Eberl R, Neumüller J, Partsch G, Bröll H (1977) Unterstützung der Frühdiagnose der ankylosierenden Spondarthritis mittels Bestimmung des HLA-B27 Antigens. Aktuell Rheumatol 2:163–167

    Google Scholar 

  11. Eastmond CJ, Rajah SM, Tovey D, Wright V (1980) Seronegative pauciarticular arthritis and HLA-B27. Ann Rheum Dis 39:231–234

    Google Scholar 

  12. van den Linden JMJP, de Cenlaer K, van Ramunde LKJ, Cats A (1977) Ankylosing spondylitis without HLA-B27. J Rheumatol 4:54–56

    Google Scholar 

  13. Schattenkirchner M, Schürer W, Diehm K, Scholz S, Albert ED (1976) Die Bedeutung der Histokompatibilitätsantigene (HLA-Antigene) für die Rheumatologie. Aktuell Rheumatol 1:23–34

    Google Scholar 

  14. Möller E, Olhagen B (1975) Studies on the major histocompatibility system in patients with ankylosing spondylitis. Tissue Antigens 6:237–246

    Google Scholar 

  15. Feldmann JL, Amor B, Kahan A, Salnick C, Delbarre F (1975) Antigene HL-AW27 intérêt diagnostique en rhumatologie. Rev Rhum 42:85–92

    Google Scholar 

  16. Russel AS, Lentle BC, Schlaut J (1976) Radiologic and scintiscan findings in HLA-B27 negative patients with ankylosing spondylitis. J Rheumatol 3:321–323

    Google Scholar 

  17. Migone N, Modena V, Daneo V, Carbonara AO, Capellini R (1978) Sacroiliitis and HLA. A clinical and genetical study. Ann Rheum Dis 37:513–517

    Google Scholar 

  18. Modena V, Migone N, Daneo V, Carbonara AO, di Vittorio S, Viara M (1978) Spondylodiscitis and ankylosing spondylitis: HLA typing and nosological implications. Ann Rheum Dis 37:510–512

    Google Scholar 

  19. Woodrow JC, Eastmond CJ (1978) HLA-B27 and the genetics of ankylosing spondylitis. Ann Rheum Dis 37:504–509

    Google Scholar 

  20. Spencer DG, Dick HM, McLelland AS, Buchanan W, Dick WC (1980) Clinical, biochemical and radiological comparison of ankylosing spondylitis patients with and without HLA-B27. Rheumatology 10:325–327

    Google Scholar 

  21. Terasaki PI, McCelland JD (1964) Microduplet assay of human serum cytotoxins. Nature 207:998–1000

    Google Scholar 

  22. Bennet H, Wood PHN (1968) Population studies of rheumatic diseases. Int Congr Ser, no 148. Excerpta Medica Foundation, Amsterdam New York London Paris Milan Tokyo Buenos Aires

    Google Scholar 

  23. Creutzig H, Beushausen C, Dach W (1979) Quantitative Knochenszintigraphie des Ileosacralgelenkes. Nucl Med 18:52–56

    Google Scholar 

  24. Caffrey A, James DCO (1973) Human lymphocyte antigen association in ankylosing spondylitis. Nature 242:121

    Google Scholar 

  25. Kellgren JH (1964) The epidemiology of rheumatic diseases. Ann Rheum Dis 23:109–122

    Google Scholar 

  26. Lawrence JS (1963) The prevalence of arthritis. Br J Clin Pract 17:699–705

    Google Scholar 

  27. Gofton JP, Lawrence JS, Bennet PH, Burch TA (1966) Sacroiliitis in eight populations. Ann Rheum Dis 25:528–532

    Google Scholar 

  28. Calin A, Fries JF (1975) Striking prevalence of ankylosing spondylitis in “healthy W27 positive males and females. N Engl J Med 293:835–839

    Google Scholar 

  29. Cohen LM, Mittal KK, Schmid FR, Rogers LF, Cohen KL (1976) Increased risk for spondylitis stigmata in apparently healthy HL-AW27 men. Ann Intern Med 84:1–7

    Google Scholar 

  30. Thorel JB, Cavelier B, Bonneau JC, Simonin JL, Ropartz C, Deshayes P (1978) Etude d'une population témoin non B27 à la recherche de la spondyl-arthrite ankylosante. Rev Rhum 45:275–282

    Google Scholar 

  31. Bitter J, Jeannet M (1978) HLA(B)27 in persistent yet reversible assymmetric oligoarthritis. Ann Rheum Dis 37:285

    Google Scholar 

  32. Grahame R, Kennedy L, Wood PHN (1975) HL-A27 and the diagnosis of back problems. Rheumatol Rehabil 14:168–172

    Google Scholar 

  33. Schattenkirchner M (1976) Die Histokompatibilitätsantigene (HLA-Antigene) bei rheumatischen Krankheiten. Therapiewoche 26:8124–8132

    Google Scholar 

  34. Baudoin PH, Landureau M (1979) Critères de diagnostic de la pelvispondylite rhumatismale sans atteinte radiologique des sacro-iliaques. Propositions de mise à jour. Rev Rhum 46:403–416

    Google Scholar 

  35. Rössner B, Rössner M, Schäfer W, Görlitz N (1980) Stellung der HLA-Serologie in der Frühdiagnostik der Spondylitis ankylosans. Dtsch Gesundheitswesen 35:713–715

    Google Scholar 

  36. Marks S, Calin A (1980) Inappropriate reliance on B27 and other tests in the assessment of patients with spondylarthropathy: A comparative study. Arthritis Rheum 6:716

    Google Scholar 

  37. Khan MA, Kushner J, Braun WE (1980) Genetic heterogeneity in primary ankylosing spondylitis. J Rheumatol 7:383–386

    Google Scholar 

  38. Khan MA, Kushner J, Braun WE (1980) Association of HLA-A2 with uveitis in HLA-B27 positive patients with ankylosing spondylitis. Arthritis Rheum 6:703 (Abstr)

    Google Scholar 

  39. Murray C, Mann DL, Gerber LN, Barth W, Perlmann S, Decker JL, Nigra TP (1980) Histocompatibility alloantigens in psoriasis and psoriatic arthritis. Evidence for the influence of multiple genes in the major histocompatibility complex. J Clin Invest 66:670–675

    Google Scholar 

  40. McLain DA, Luehrmann LK, Rodey GE, Schwartz BD (1980) An HLA public antigen is more common than HLA-B27 in patients with ankylosing spondylitis. Clin Res 28:354A (Abstr)

    Google Scholar 

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Authors and Affiliations

  1. Division of Metabolic and Rheumatic Diseases, Medical School of Hannover, D-3000, Hannover, Germany

    H. Zeidler & P. Wagener

  2. Division of Immunology and Transfusion Medicine, Medical School of Hannover, D-3000, Hannover, Germany

    G. Eckert & H. Deicher

  3. Division of Radiology, Medical School of Hannover, D-3000, Hannover, Germany

    J. Freyschmidt & R. Fritsch

  4. Division of Nuclear Medicine, Medical School of Hannover, D-3000, Hannover, Germany

    H. Creutzig

Authors
  1. H. Zeidler
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  2. P. Wagener
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  3. G. Eckert
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  4. J. Freyschmidt
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  5. R. Fritsch
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  6. H. Creutzig
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  7. H. Deicher
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Zeidler, H., Wagener, P., Eckert, G. et al. HLA-B27 in possible ankylosing spondylitis with peripheral arthritis. Rheumatol Int 2, 35–40 (1982). https://doi.org/10.1007/BF00541269

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  • DOI: https://doi.org/10.1007/BF00541269

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