Rheumatology International

, Volume 1, Issue 3, pp 115–120 | Cite as

Concanavalin A-induced suppressor cell activity and in vitro immunoglobulin secretion in rheumatoid arthritis: Correlation with clinical and immunological parameters

  • J. S. Smolen
  • G. Lanzer
  • O. Scherak
  • E. J. Menzel
  • W. R. Mayr
  • C. Steffen
  • W. Knapp


Concanavalin A-induced suppressor cell activity was found moderately but significantly (P<0.05) decreased in RA patients treated with nonsteroidal antiinflammatory drugs (31±7% suppression) as compared to patients on remission-inducing drugs, such as gold, penicillamine, or chloroquine (51±6%) or to healthy individuals (50±6%). Also, lymphocytes from patients with antibodies to collagen mediated lower suppression (33±7%) than lymphocytes from patients without evidence for these autoantibodies (61±11%). No significant difference between patients and controls or between individual groups of patients were observed in regard to IgM and IgG secretion induced by pokeweed mitogen. Thus, although no indication for a severe derangement of regulatory cells in peripheral blood of RA patients could be observed in this study, a slight deficiency of ConA-inducible suppressor cells that may be reverted by remission-inducing drugs seems to be present in RA.

Key words

Rheumatoid arthritis Suppressor cells Immunoglobulin secretion HLA DR antigens 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. S. Smolen
    • 1
  • G. Lanzer
    • 1
  • O. Scherak
    • 1
  • E. J. Menzel
    • 1
  • W. R. Mayr
    • 1
  • C. Steffen
    • 1
  • W. Knapp
    • 1
  1. 1.Second Department of Internal Medicine, Institute of Immunology, and Institute of Blood Group SerologyUniversity of ViennaViennaAustria

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