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HLA-DR antigens in rheumatoid arthritis

A Swiss collaborative study

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Summary

In a Swiss multicenter study, a significant increase of HLA-DR4 was found in patients with rheumatoid arthritis when compared with normal controls (P<0.01). This increase was limited to patients with rheumatoid factors; it was strongest in patients with high titers. Similarly, the frequency of HLA-DR4 was higher in patients with larger amounts of circulating immune complexes when compared with patients with low amounts. No correlation with the presence of antinuclear antibodies was found. HLA-DR1 was more frequent in patients with rheumatoid arthritis than in controls (N.S.). This was due to an increase of HLA-DR1 in patients without rheumatoid factors (P<0.05), low amounts of circulating immune complexes (N.S.) and without antinuclear antibodies (P<0.05).

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Consortia

Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research

Additional information

Participants: T. L. Vischer (coordination and correspondence), Division of Rheumatology, Hôpital Cantonal, CH-1211 Genève 4;

M. Jeannet and V. von Fliedner (HLA-antigen determinations), Transplantation Immunology Unit, Division of Immunology; A. Cruchaud (antinuclear antibodies), Division of Immunology; A. Micheli (rheumatoid factors), Division of Rheumatology; N. Carpentier and P.H. Lambert (C1q-binding tests), WHO Immunology Research and Training Laboratory; all from the Department of Medicine, University of Geneva. P. Vuagnat (statistics), Department of Mathematics, University of Geneva

Centers: Basel: U. Steiger (Medizinische Universitätsklinik); Bern: N. Gerber (Universitäts-Rheumaklinik); Fribourg: I. Radi (Hôpital Cantonal); Genève: T. L. Vischer (Hôpital Cantonal); La Chaux-de-Fonds: H. Ott (Service de Physiatrie, Hôpital de la Chaux-de-Fonds); Lausanne: T. Bitter and J. C. Gerster (Service de Physiatrie, CHUV);

Leukerbad: N. Fellmann (Rheumaklinik); Valens: B. Stojan (Klinik Valens); Winterthur: H. Hunziker (Kantonsspital); Zürich: M. Baumgartner (Klinik Wilhelm Schulthess), D. Gross and M. Lamoth (Triemlispital), K. Fehr and M. Felder (Universitäts-Rheumaklinik); Zurzach: W. Kunz (Rheumaklinik)

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Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research. HLA-DR antigens in rheumatoid arthritis. Rheumatol Int 1, 111–113 (1981). https://doi.org/10.1007/BF00541254

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