Summary
It has recently been suggested that a subpopulation of patients with rheumatoid arthritis, diagnosed on clinical, radiologic and pragmatic grounds, but with negative rheumatoid factor tests, represents a clinical entity quite distinct from that of seropositve rheumatoid arthritis. We have studied 60 sequentially presenting patients, 30 of whom were selected because they were seronegative, and 30 selected because they were seropositive in regard to IGM rheumatoid factor. The only major differences detected between the two groups on ‘blind’ assessment were a greater tendency to deformity, a greater degree of erosion and the presence of subcutaneous nodules in the seropositive group. Seronegative and seropositive rheumatoid arthritis appear to have very similar clinical features, but differing degrees of severity.
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References
Carson DA (1981) Rheumatoid factor. In: Kelly WN, Harris ED, Ruddy S, Sledge CB (eds) Textbook of rheumatology. Saunders, Philadelphia, pp 677–690
Calin A, Marks SH (1981) The case against seronegative rheumatoid arthritis. Am J Med 70:992–994
Alarcon GS, Koopman WJ, Acton RT, Barger BO (1982) Seronegative rheumatoid arthritis: A distinct immunological disease? Arthritis Rheum 25:502–507
Burns T, Calin A (1982) The hand radiograph as a diagnostic discriminant between seronegative and seropositíve “rheumatoid arthritis”: A controlled study. Arthritis Rheum 25 (Suppl): S124
Masi AT, Maldonado-Cocco JA, Kaplan SB, Feigenbaum SL, Chandler RW (1976) Prospective study of the early course of rheumatoid arthritis in young adults: comparison of patients with and without rheumatoid factor positivity at entry and identification of variables correlating with outcome. Semin Arthritis Rheum 5:299–326
Linn JE, Hardin JG, Halla JT (1978) A controlled study of ANA + RF — arthritis. Arthritis Rheum 21:645–651
Bland JH, Brown EW (1964) Seronegative and seropositive rheumatoid arthritis: Clinical radiological and biochemical differences. Ann Intern Med 60:88–94
Ropes MW, Bennett GA, Cobb S, Jacox R, Jessar RA (1959) 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175–176
Russell AS, Schlaut J (1975) HL-A transplantation antigens in subjects susceptible to recrudescent herpes labialis. Tissue Antigens 6:257–261
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Edelman, J., Russell, A.S. A comparison of patients with seropositive and seronegative rheumatoid arthritis. Rheumatol Int 3, 47–48 (1983). https://doi.org/10.1007/BF00541233
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DOI: https://doi.org/10.1007/BF00541233