Rheumatology International

, Volume 3, Issue 1, pp 1–5 | Cite as

Sjögren's syndrome in systemic lupus erythematosus and rheumatoid arthritis: Immune effector cells in salivary glands

  • Maria Malmström
  • Anu Seppä
  • Yrjö T. Konttinen
  • Tapani Helve
  • Sakari Reitamo


A simultaneously capturing azo dye method for acid α-naphthyl acetate esterase was used to characterize the cellular infiltrate in labial salivary glands in 25 patients with Sjögren's syndrome (SS). There was no significant difference in the T-pattern lymphocyte percentage in situ between the untreated group with SS and the group treated with 10±2 mg prednisone/day. There was a significant correlation (P<0.05) between the T-pattern lymphocyte percentage in situ and the focus-score value. In secondary (2°) SS in cases of systemic lupus erythematosus (SLE) and rheumatoid arthritis, respectively, 55%±4% (range 41–69) and 43%±7% (range 15–80) of all inflammatory cells in the periductal lymphocyte-rich infiltrates were T-pattern lymphocytes. In other SS patients the corresponding value was 28%±7% (range 4–50). The T-pattern lymphocyte percentage in situ was dependent on the disorder associated with SS (P=0.07). The present results indicate the dominance of T-lymphocytes in situ in 2° SS with SLE and suggest that there are differences in cell-mediated immunity in different clinical subgroups of SS.

Key words

Sjögren's syndrome Rheumatoid arthritis Systemic lupus erythematosus Salivary glands Lymphocytes 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Maria Malmström
    • 1
  • Anu Seppä
    • 1
    • 2
  • Yrjö T. Konttinen
    • 1
  • Tapani Helve
    • 1
  • Sakari Reitamo
    • 3
  1. 1.Institute of Dentistry, Department of Oral SurgeryUniversity of HelsinkiHelsinki 28Finland
  2. 2.Fourth Department of MedicineUniversity of HelsinkiHelsinki 17Finland
  3. 3.College of Physicians and Surgeons, Institute of Cancer ResearchColumbia UniversityNew YorkUSA

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