Rheumatology International

, Volume 1, Issue 4, pp 171–175 | Cite as

Human lymphocyte response to selected infectious agents in Reiter's syndrome and ankylosing spondylitis

  • R. W. Enlow
  • W. B. Bias
  • R. Bluestone
  • F. C. Arnett


Reiter's syndrome (RS) and idiopathic ankylosing spondylitis (AS) have been associated with certain infections and the histocompatibility antigen HLA-B27. The proliferative responses of peripheral mononuclear cell preparations from 18 patients with RS, 6 with AS, and 22 unaffected subjects were studied toward Shigella flexneri, Salmonella typhimurium, Yersinia enterocolitica, Klebsiella pneumoniae, and Chlamydia trachomatis. Although RS, AS, and HLA-B27-positive normal subjects had generally higher mean responses than HLA-B27-negative controls, no significant differences were demonstrated. Using a chromium release assay, the cytotoxicity of an HLA-B27 antiserum was not altered by preincubation of lymphocytes with these organisms for several individual subjects in each study group.

Key words

Reiter's syndrome Ankylosing spondylitis Reactive arthritis HLA-B27 


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Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • R. W. Enlow
    • 1
    • 2
  • W. B. Bias
    • 1
    • 2
  • R. Bluestone
    • 1
    • 2
  • F. C. Arnett
    • 1
    • 2
  1. 1.Rheumatology Division and Immunogenetics LaboratoryThe Johns Hopkins University School of Medicine and Hospital and the Good Samaritan HospitalBaltimoreUSA
  2. 2.The Wadsworth Veteran's Administration HospitalLos AngelesUSA

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