European Journal of Clinical Pharmacology

, Volume 34, Issue 3, pp 307–308 | Cite as

Acetylator polymorphism in discoid lupus erythematosus

  • J. M. Ladero
  • L. C. Jiménez
  • M. J. Fernández
  • A. Robledo
Short Communications


Acetylator phenotype was determined, using sulphamethazine, in 37 patients with histologically confirmed discoid lupus erythematosus, who were free from visceral damage, and in 157 normal control subjects. Twenty patients (54%) and 90 control subjects (57.4%) were slow acetylators (p not significant). Acetylator polymorphism appears not to be related to the risk of developing pure cutaneous discoid lupus erythematosus.

Key words

acetylator phenotype lupus erythematosus sulphamethazine 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • J. M. Ladero
    • 1
  • L. C. Jiménez
    • 1
  • M. J. Fernández
    • 1
  • A. Robledo
    • 1
  1. 1.Departments of Medicine and Medicine II (Dermatology)Hospital Universitario “San Carlos”, Facultad de Medicina, Universidad ComplutenseMadridSpain

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