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European Journal of Clinical Pharmacology

, Volume 34, Issue 3, pp 263–266 | Cite as

Beta-blockade antagonism of tyramine-induced rise in blood pressure

  • F. Colombo
  • R. Sega
  • F. Mailland
  • R. Rigo
  • L. Palvarini
  • A. Libretti
Originals

Summary

The effect β-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1–6 mg, alternating with saline, in a randomized, single blind fashion.

Prior to treatment tyramine caused a temporary, dose-dependent increase in systolic and diastolic blood pressure, whilst the heart rate remained unaffected. Both propranolol and indenolol reduced the pressor response to tyramine, as shown by a significant increase in ED15, i.e. the dose of tyramine required to increase systolic blood pressure by 15%.

Key words

tyramine propranolol pressure response blood pressure beta-adrenoceptor blockers healthy volunteers indenolol 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. Colombo
    • 1
  • R. Sega
    • 1
  • F. Mailland
    • 2
  • R. Rigo
    • 1
  • L. Palvarini
    • 1
  • A. Libretti
    • 1
  1. 1.Institute of Internal MedicineL. Sacco Hospital University of MilanMilanItaly
  2. 2.POLI Research CentreMilanItaly

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