Intercellular communication, three-dimensional cell contact and radiosensitivity
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a correlation between cell coupling and the activity of adenylate cyclase in monolayers,
a sharp drop of cyclase activity in spheroids of coupled cells compared to monolayers, and
a decrease of coupling with age (“maturation”) of the spheroids.
These results suggest profound physiological alterations in communicating cells induced under conditions of tight three-dimensional contact as a possible cause for the reduced radiosensitivity of spheroids.
Key wordsIntercellular communication Spheroids Adenylate cyclase Radiosensitivity
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