Abstract
Subpopulations of different proliferative status are determined during cell-density dependent proliferation of 3T3 cells. From these data the probability of conversion of proliferative to quiescent cells is derived and found to correlate well with published data on binding of growth-inhibiting factors secreted from growth-inhibited cells.
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References
Adam G, Schumann C (1981) Dependence of interfacial properties of normal and transformed 3T3 cell membranes on treatment with factors modifying proliferation. Cell Biophys 3: 189–209
Holley R (1975) Control of growth of mammalian cells in cell culture. Nature 258: 487–490
Holley R (1980) Control of animal cell proliferation. J Supramol Struct 13: 191–197
Lieberman MA, Glaser L (1981) Density-dependent regulation of cell growth: An example of a cell-cell recognition phenomenon. J Membr Biol 63: 1–11
Steck PA, Blenis J, Voss PG, Wang JL (1982) Growth control in cultured 3T3 fibroblasts II. olecular properties of a fraction enriched in growth inhibitory acticity. J Cell Biol 92: 523–530
Vogel A, Ross R, Raines E (1980) Role of serum components in density-dependent inhibition of growth of cells in culture. J Cell Biol 85: 377–385
Voss PG, Steck PA, Calamia JC, Wang JL (1982) Growth control in cultured 3T3 fibroblasts III. Binding interactions of a growth inhibitory activity with target cells. Exp Cell Res 138: 397–407
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Adam, G., Steiner, U., Maier, H. et al. Analysis of cellular interactions in density-dependent inhibition of 3T3 Cell proliferation. Biophys. Struct. Mechanism 9, 75–82 (1982). https://doi.org/10.1007/BF00539104
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DOI: https://doi.org/10.1007/BF00539104